Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
. 2021 Sep 2;17(9):2999-3015.
doi: 10.1080/21645515.2021.1911217. Epub 2021 Jun 21.

Vaccinomics: a cross-sectional survey of public values

Jennifer E Gerber  1 , Janesse Brewer  1 , Rupali J Limaye  1   2   3   4   5 , Andrea Sutherland  1 , Madeleine Blunt  1 , Taylor A Holroyd  1   4 , Gail Geller  3   6   7   8 , Bruce Carleton  9   10   11 , Jeffery Kahn  6 , Daniel A Salmon  1   3   5
Affiliations

Vaccinomics: a cross-sectional survey of public values

Jennifer E Gerber et al. Hum Vaccin Immunother. .

Abstract

Objective: We characterize public values regarding vaccinomics, which aims to improve vaccine safety and effectiveness using genomics.Methods: Panel survey (2020) of ≥18-year-olds with embedded animation introduced vaccinomics. Sociodemographic, health, and vaccination-related items were adapted from validated scales. Novel items measured trust in public health authorities, vaccinomics-related values, and preferences for federal funding: vaccinomics compared with vaccine issues and chronic diseases. Beginning and end of survey confidence in vaccine safety was measured to assess potential changes. Data were weighted to the U.S. Census. Vaccinomics-related concerns were stratified by sociodemographic characteristics, vaccine hesitancy status (composite outcome), reported serious vaccine reactions, and trust in public health authorities (PHA). Log binomial regression models estimated associations between these variables and agency to make vaccine-related decisions.Results: Most (70.7%, N = 1,925) respondents expected vaccinomics would increase their vaccine confidence compared to now. Agreement was highest among those without serious vaccine reaction experience (unexperienced: 74.2% versus experienced: 62.3%), with high trust in PHA (high: 83.3% versus low: 57.4%), and low vaccine hesitancy among parents of teenagers (low: 78.8% versus high: 62.5%) and adults without minor children (low: 79.8% versus high: 60.6%; all p < .01). Belief that vaccination was an individual's choice was associated with reported serious reactions (adjusted Prevalence Ratio (aPR): 1.16; 95% CI: 1.07, 1.25) and low trust (aPR: 0.91; 0.84, 0.98). Beginning versus end of survey vaccine safety perceptions were similar.Conclusion: Federal funding, communications, and policies should assure the public that vaccinomics will not remove their decision-making power and engender trust in PHA.

Keywords: Vaccinomics; adversomics; cross-sectional survey; genomics; panel survey; qualtrics; vaccine hesitancy; vaccine policy; web panel.

PubMed Disclaimer

Figures

Figure 1.
Figure 1.
A. Vaccine hesitancy among parents of  young children 10 years old and younger, B. Vaccine hesitancy among parents of children  11 to 17 years old, and C. Vaccine hesitancy among parents without minor children
See this image and copyright information in PMC

References

    1. Poland GA, Kennedy RB, McKinney BA, Ovsyannikova IG, Lambert ND, Jacobson RM, Oberg AL.. Vaccinomics, adversomics, and the immune response network theory: individualized vaccinology in the 21st century. Semin Immunol. 2013;25(2):89–103. doi: 10.1016/j.smim.2013.04.007. - DOI - PMC - PubMed
    1. Poland GA, Ovsyannikova IG, Kennedy RB. Personalized vaccinology: a review. Vaccine. 2018;36(36):5350–57. doi: 10.1016/j.vaccine.2017.07.062. - DOI - PMC - PubMed
    1. Poland GA, Jacobson RM, Ovsyannikova IG. Trends affecting the future of vaccine development and delivery: the role of demographics, regulatory science, the anti-vaccine movement, and vaccinomics. Vaccine. 2009;27(25–26):3240–44. doi: 10.1016/j.vaccine.2009.01.069. - DOI - PMC - PubMed
    1. Poland GA, Ovsyannikova IG, Jacobson RM, Smith DI. Heterogeneity in vaccine immune response: the role of immunogenetics and the emerging field of vaccinomics. Clin Pharmacol Ther. 2007;82(6):653–64. doi: 10.1038/sj.clpt.6100415. - DOI - PubMed
    1. World Health Administration . Adverse events following immunization (AEFI). Global Vaccine Safety; 2018. [accessed 2019 Oct 29]. https://www.who.int/vaccine_safety/initiative/detection/AEFI/en/.

Publication types