Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
Comment
. 2021 Nov;75(5):1250-1252.
doi: 10.1016/j.jhep.2021.06.009. Epub 2021 Jun 18.

Autoimmune hepatitis following COVID-19 vaccination: True causality or mere association?

Chin Kimg Tan  1 , Yu Jun Wong  1 , Lai Mun Wang  2 , Tiing Leong Ang  1 , Rahul Kumar  3
Affiliations
Comment

Autoimmune hepatitis following COVID-19 vaccination: True causality or mere association?

Chin Kimg Tan et al. J Hepatol. 2021 Nov.
No abstract available

Keywords: Autoimmune Hepatitis; COVID-19; mRNA Vaccine.

PubMed Disclaimer

Conflict of interest statement

Conflict of interest All authors do not have any potential conflict of interest to declare. Please refer to the accompanying ICMJE disclosure forms for further details.

Figures

Fig. 1
Fig. 1
Liver function test and histology of liver biopsy. (A) Graph showing the trend of bilirubin (μmol/L) and alanine aminotransferase (U/L) before and after starting treatment with budesonide on 1-June 2021. (B) H&E-stained section of liver biopsy at 200x magnification showing a portal tract with portal inflammation and interface damage. (C) Higher magnification (400x) of the portal and interface inflammatory cells showing aggregates of plasma cells, lymphocytes and few eosinophils. (D) Within the liver parenchyma (200x magnification), there is lobulitis with clusters of plasma cells, rosette formation and apoptotic hepatocytes. (E) The Masson’s trichrome stain (100x magnification) showed pale green staining of the portal regions with a lack of elastic fibres seen on orcein stain (inset, 100x magnification), consistent with recent young fibrosis. Elastic fibres appear black on orcein stains and are usually absent in normal portal tracts. Old fibrosis type collagen contains elastic fibres and is a useful indicator of chronicity on histology. (This figure appears in color on the web.)
See this image and copyright information in PMC

Comment in

Comment on

References

    1. Baden L.R., El Sahly H.M., Essink B., Kotloff K., Frey S., Novak R., et al. Efficacy and safety of the mRNA-1273 SARS-CoV-2 vaccine. N Engl J Med. 2021;384(5):403–416. - PMC - PubMed
    1. Bril F., Al Diffalha S., Dean M., Fettig D.M. Autoimmune hepatitis developing after coronavirus disease 2019 (COVID-19) vaccine: causality or casualty? J Hepatol. 2021;75:222–224. - PMC - PubMed
    1. Capecchi P.L., Lazzerini P.E., Brillanti S. Comment to the letter of Bril F et al. “Autoimmune hepatitis developing after coronavirus disease 2019 (COVID-19) Vaccine: causality or casualty?”. J Hepatol. 2021;75:994–995. - PMC - PubMed
    1. Robles-Diaz M., Lucena M.I., Kaplowitz N., Stephens C., Medina-Cáliz I., González-Jimenez A., et al. Use of Hy's law and a new composite algorithm to predict acute liver failure in patients with drug-induced liver injury. Gastroenterology. 2014;147(1):109–118. - PubMed
    1. Alvarez F., Berg P.A., Bianchi F.B., Bianchi L., Burroughs A.K., Cancado E.L., et al. International Autoimmune Hepatitis Group Report: review of criteria for diagnosis of autoimmune hepatitis. J Hepatol. 1999;31:929–938. - PubMed

Substances