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Review
. 2021 Nov 5:223:113632.
doi: 10.1016/j.ejmech.2021.113632. Epub 2021 Jun 15.

Recent advances of quinones as a privileged structure in drug discovery

Li Zhang  1 , Guiying Zhang  2 , Shujing Xu  3 , Yuning Song  4
Affiliations
Review

Recent advances of quinones as a privileged structure in drug discovery

Li Zhang et al. Eur J Med Chem. .

Abstract

Privileged structures are conductive to discover novel bioactive substances because they can bind to multiple targets with high affinity. Quinones are considered to be a privileged structure and useful template for the design of new compounds with potential pharmacological activity. This article presents the recent developments (2014-2021 update) of quinones in the fields of antitumor, antibacterial, antifungal, antiviral, anti-Alzheimer's disease (AD) and antimalarial, mainly focusing on biological activities, structural modification and mechanism of action.

Keywords: Biological activities; Mechanism of action; Privileged structure; Quinones; Structural modification.

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Conflict of interest statement

Declaration of competing interest The authors declare that they have no known competing financial interests or personal relationships that could have appeared to influence the work reported in this paper.

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