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Comment
. 2021 Oct;46(10):787-789.
doi: 10.1016/j.tibs.2021.06.004. Epub 2021 Jun 19.

Lipidation status of single membrane-associated ATG8 proteins

Christophe Viret  1 , Mathias Faure  2
Affiliations
Comment

Lipidation status of single membrane-associated ATG8 proteins

Christophe Viret et al. Trends Biochem Sci. 2021 Oct.

Abstract

ATG8 are core autophagy proteins, the lipidated forms of which decorate double-membraned autophagosomes, as well as single-membraned organelles such as endolysosomes. Recent studies from the Florey and Münz laboratories delineate the status of single membrane-associated ATG8 proteins by indicating that their membrane anchoring can involve phosphatidylserine conjugation and their stabilization depends on ATG4 protease inhibition.

Keywords: ATG4 proteases; ATG8 proteins; aminoglycerophospholipids; lipidation; noncanonical autophagy; oxidation.

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