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Review
. 2021 May 18;13(5):e15087.
doi: 10.7759/cureus.15087.

A Review of Epidemiology and Cancer Biology of Malignant Melanoma

Matthew G Davey  1 , Nicola Miller  1 , Niall M McInerney  2
Affiliations
Review

A Review of Epidemiology and Cancer Biology of Malignant Melanoma

Matthew G Davey et al. Cureus. .

Abstract

Malignant melanoma is a neoplasm originating in the melanocytes in the skin. Although malignant melanoma is the third most common cutaneous cancer, it is recognized as the main cause of skin cancer-related mortality, and its incidence is rising. The natural history of malignant melanoma involves an inconsistent and insidious skin cancer with great metastatic potential. Increased ultra-violet (UV) skin exposure is undoubtedly the greatest risk factor for developing cutaneous melanoma; however, a plethora of risk factors are now recognized as causative. Moreover, modern oncology now considers melanoma proliferation a complex, multifactorial process with a combination of genetic, epigenetic, and environmental factors all known to be contributory to tumorgenesis. Herein, we wish to outline the epidemiological, molecular, and biological processes responsible for driving malignant melanoma proliferation.

Keywords: biology; epidemiology; melanoma; oncology; skin cancer.

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Conflict of interest statement

The authors have declared that no competing interests exist.

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