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. 2021 Aug;78(8):3058-3067.
doi: 10.1007/s00284-021-02560-3. Epub 2021 Jun 22.

Antimicrobial Activity and Functional Genes of Actinobacteria from Coastal Wetland

Lei Chen  1 , Ziwei Wang  1 , Shuang Du  1 , Guangyu Wang  2
Affiliations

Antimicrobial Activity and Functional Genes of Actinobacteria from Coastal Wetland

Lei Chen et al. Curr Microbiol. 2021 Aug.

Abstract

Isolation of culturable actinobacteria from coastal wetlands and screening of their potential biological activities are important for the development of new marine natural products. We collected and isolated 109 actinobacteria from the Sanggou Bay and the Swan Lake wetlands, in the coast of Weihai, China. Of the 109 isolates, 104 had antimicrobial activity against at least one indicator strain. The 35 strains with the strongest inhibitory effects were chosen for the screening of the biosynthesis gene clusters of polyketide synthase (PKS) and non-ribosomal peptide synthetase (NRPS). Four strains with the PKS gene, six strains with the NRPS gene, and three strains with both genes were detected. Eight of the 13 strains with PKS or NRPS genes belong to the genera Streptomyces, and other strains belonged to genus Micromonospora, Nocardiopsis, Rhodococcus, Saccharomonospora, and Staphylococcus. Our results reveal that the culturable actinobacteria isolated from coastal wetlands showed broad-spectrum antimicrobial activities, and some strains with antimicrobial activities possessed PKS and NRPS genes. Thus, culturable actinobacteria from coastal wetlands may contain potential new bioactive substances.

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