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. 2022 Jul;14(7):753-763.
doi: 10.1002/pmrj.12657. Epub 2021 Aug 16.

Prevalence of depression and anxiety disorders following mild traumatic brain injury

Richard L Delmonico  1 , Brian R Theodore  1 , M Elizabeth Sandel  2 , Mary Anne Armstrong  3 , Michelle Camicia  1
Affiliations

Prevalence of depression and anxiety disorders following mild traumatic brain injury

Richard L Delmonico et al. PM R. 2022 Jul.

Abstract

Background: Previous studies have identified an association between traumatic brain injuries and the development of psychiatric disorders in general. However, these studies were subject to limitations that demonstrate the need for a study of a large, clearly defined mild traumatic brain injury (mTBI) population within an integrated healthcare system.

Objective: To determine the prevalence and relative risk of postinjury affective disorders over 4 years following mTBI.

Design: Cohort study of mTBI cases and matched controls, over a 4-year period.

Setting: An integrated healthcare delivery system in California.

Patients: A total of 9428 adult health plan members diagnosed with mTBI from 2000-2007 and enrolled in the year before injury, during which no TBI was ascertained. Control participants included 18,856 individuals selected based on the following criteria: Two unexposed health plan members per each mTBI-exposed patient were randomly selected and individually matched for age, gender, race/ethnicity, and medical comorbidities.

Interventions: Not applicable.

Main outcome measures: A diagnosis of affective disorder (depressive, anxiety, and adjustment disorders) in the 4 years after mTBI or the reference date, determined according to the International Classification of Diseases, Ninth Revision, Clinical Modification as well as the Diagnostic and Statistical Manual of Mental Disorders, 4th Edition, Text Revision.

Results: Affective disorders were most prominent during the first 12 months with 23% following mTBI and 14% in the control group. Four-year aggregate adjusted odds ratios for having an affective disorder following mTBI were 1.2 (95% CI: 1.1, 1.2; p < .001) and 1.5 (95% CI: 1.5, 1.6; p < .001) for patients with and without prior affective disorders, respectively.

Conclusion: mTBI was associated with a significantly increased risk of having subsequent affective disorders. Screening for and addressing affective disorders at earlier stages following the injury is an important step to avoid persisting conditions that may pose a barrier to full recovery.

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References

REFERENCES

    1. Lindquist LK, Love HC, Elbogen EB. Traumatic brain injury in Iraq and Afghanistan veterans: new results from a national random sample study. J Neuropsychiatry Clin Neurosci. 2017;29(3):254-259.
    1. Lau KM, Madden E, Neylan TC, Seal KH, Maguen S. Assessing for mild TBI among Iraq and Afghanistan veterans: outcomes of injury severity and neurological factors. Brain Inj. 2016;30(3):287-294.
    1. Coxe K, Hamilton K, Harvey HH, Xiang J, Ramirez MR, Yang J. Consistency and variation in school-level youth sports traumatic brain injury policy content. J Adolesc Health. 2018;62(3):255-264.
    1. Vos BC, Nieuwenhuijsen K, Sluiter JK. Consequences of traumatic brain injury in professional American football players: a systematic review of the literature. Clin J Sport Med. 2018;28(2):91-99.
    1. Yue JK, Winkler EA, Burke JF, et al. Pediatric sports-related traumatic brain injury in United States trauma centers. Neurosurg Focus. 2016;40(4):E3.

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