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Comment
. 2021 Jun 21;56(12):1697-1699.
doi: 10.1016/j.devcel.2021.06.002.

Understanding totipotency: A role for alternative splicing

Alejandro De Los Angeles  1 , Pentao Liu  2
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Understanding totipotency: A role for alternative splicing

Alejandro De Los Angeles et al. Dev Cell. .
Free article

Abstract

Totipotency refers to single cells' developmental capacity to form an entire organism. Understanding how totipotent stem cells form has implications for chimera generation. In a recent Cell study, Shen et al. (2021) report that inhibition of spliceosomes resets conventional pluripotent stem cells to a cellular state with totipotency features.

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Conflict of interest statement

Declaration of interests The authors declare no competing interests.

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