Randomized Controlled Trial

. 2021 Oct:237:148-153.e3.

doi: 10.1016/j.jpeds.2021.06.026. Epub 2021 Jun 19.

Growth Rates of Infants Randomized to Continuous Positive Airway Pressure or Intubation After Extremely Preterm Birth

Collaborators, Affiliations

Collaborators

Eunice Kennedy Shriver National Institute of Child Health and Human Development Neonatal Research Network:
Alan H Jobe, Michael S Caplan, Abbot R Laptook, William Oh, Betty R Vohr, Angelita M Hensman, Bonnie E Stephens, Barbara Alksninis, Dawn Andrews, Kristen Angela, Susan Barnett, Bill Cashore, Melinda Caskey, Kim Francis, Dan Gingras, Regina A Gargus, Katharine Johnson, Shabnam Lainwala, Theresa M Leach, Martha R Leonard, Sarah Lillie, Kalida Mehta, James R Moore, Lucy Noel, Suzy Ventura, Rachel V Walden, Victoria E Watson, Michele C Walsh, Avroy A Fanaroff, Nancy S Newman, Deanne E Wilson-Costello, Bonnie S Siner, Arlene Zadell, Julie DiFiore, Monika Bhola, Harriet G Friedman, Gulgun Yalcinkaya, Kurt Schibler, Edward F Donovan, Kimberly Yolton, Vivek Narendran, Kate Bridges, Barbara Alexander, Cathy Grisby, Marcia Worley Mersmann, Holly L Mincey, Jody Hessling, Teresa L Gratton, Ronald N Goldberg, C Michael Cotten, Ricki F Goldstein, Patricia Ashley, Kathy J Auten, Kimberley A Fisher, Katherine A Foy, Sharon F Freedman, Kathryn E Gustafson, Melody B Lohmeyer, William F Malcolm, David K Wallace, Barbara J Stoll, Susie Buchter, Anthony J Piazza, David P Carlton, Ira Adams-Chapman, Linda Black, Ann M Blackwelder, Sheena Carter, Elisabeth Dinkins, Sobha Fritz, Ellen C Hale, Amy K Hutchinson, Maureen Mulligan LaRossa, Gloria V Smikle, Stephanie Wilson Archer, James A Lemons, Anna M Dusick, Leslie D Wilson, Faithe Hamer, Ann B Cook, Dianne E Herron, Carolyn Lytle, Heike M Minnich, Mary Anne Berberich, Carol J Blaisdell, Dorothy B Gail, James P Kiley, W Kenneth Poole, Marie G Gantz, Jamie E Newman, Betty K Hastings, Jeanette O'Donnell Auman, Carolyn Petrie Huitema, James W Pickett 2nd, Dennis Wallace, Kristin M Zaterka-Baxter, David K Stevenson, Susan R Hintz, M Bethany Ball, Barbara Bentley, Elizabeth F Bruno, Alexis S Davis, Maria Elena DeAnda, Anne M DeBattista, Jean G Kohn, Melinda S Proud, Renee P Pyle, Nicholas H St John, Hali E Weiss, Ivan D Frantz 3rd, John M Fiascone, Elisabeth C McGowan, Anne Furey, Brenda L MacKinnon, Ellen Nylen, Ana Brussa, Cecelia Sibley, Namasivayam Ambalavanan, Monica V Collins, Shirley S Cosby, Myriam Peralta-Carcelen, Vivien A Phillips, Kirstin J Bailey, Fred J Biasini, Maria Hopkins, Kristen C Johnston, Sara Krzywanski, Kathleen G Nelson, Cryshelle S Patterson, Richard V Rector, Leslie Rodriguez, Amanda Soong, Sally Whitley, Sheree York, Neil N Finer, Maynard R Rasmussen, Paul R Wozniak, Yvonne E Vaucher, Wade Rich, Kathy Arnell, Rene Barbieri-Welge, Ayala Ben-Tall, Renee Bridge, Clarence Demetrio, Martha G Fuller, Elaine Ito, Meghan Lukasik, Deborah Pontillo, Donna Posin, Cheryl Runyan, James Wilkes, Paul Zlotnik, John A Widness, Jonathan M Klein, Tarah T Colaizy, Karen J Johnson, Michael J Acarregui, Diane L Eastman, Shahnaz Duara, Charles R Bauer, Ruth Everett-Thomas, Maria Calejo, Alexis N Diaz, Silvia M Frade Eguaras, Andrea Garcia, Kasey Hamlin-Smith, Michelle Harwood Berkowits, Sylvia Hiriart-Fajardo, Elaine O Mathews, Helina Pierre, Arielle Riguard, Alexandra Stroerger, Robin K Ohls, Janell Fuller, Julie Rohr, Conra Backstrom Lacy, Jean Lowe, Rebecca Montman, Nirupama Laroia, Dale L Phelps, Gary J Myers, Gary David Markowitz, Linda J Reubens, Diane Hust, Lisa Augostino, Julie Babish Johnson, Erica Burnell, Harris Gelbard, Rosemary L Jensen, Emily Kushner, Joan Merzbach, Jonathan Mink, Carlos Torres, David Wang, Kelley Yost, Pablo J Sánchez, Charles R Rosenfeld, Walid A Salhab, Roy J Heyne, Sally S Adams, James Allen, Laura Grau, Alicia Guzman, Gaynelle Hensley, Elizabeth T Heyne, Melissa H Lepps, Linda A Madden, Melissa Martin, Nancy A Miller, Janet S Morgan, Araceli Solis, Lizette E Torres, Catherine Twell Boatman, Diana M Vasil, Kerry Wilder, Kathleen A Kennedy, Jon E Tyson, Nora I Alaniz, Patricia W Evans, Beverly Foley Harris, Charles Green, Margarita Jiminez, Anna E Lis, Sarah Martin, Georgia E McDavid, Brenda H Morris, Margaret L Poundstone, Stacy Reddoch, Saba Siddiki, Patti L Pierce Tate, Laura L Whitely, Sharon L Wright, Bradley A Yoder, Roger G Faix, Shawna Baker, Karie Bird, Jill Burnett, Laura Cole, Karen A Osborne, Cynthia Spencer, Mike Steffens, Kimberlee Weaver-Lewis, Karen Zanetti, T Michael O'Shea, Robert G Dillard, Lisa K Washburn, Nancy J Peters, Barbara G Jackson, Korinne Chiu, Deborah Evans Allred, Donald J Goldstein, Raquel Halfond, Carroll Peterson, Ellen L Waldrep, Cherrie D Welch, Melissa Whalen Morris, Gail Wiley Hounshell, Athina Pappas, Beena G Sood, Rebecca Bara, Elizabeth Billian, Laura A Goldston, Mary Johnson, Richard A Ehrenkranz, Vineet Bhandari, Harris C Jacobs, Pat Cervone, Patricia Gettner, Monica Konstantino, JoAnn Poulsen, Janet Taft, Christine G Butler, Nancy Close, Walter Gilliam, Sheila Greisman, Elaine Romano, Joanne Williams

Affiliations

¹ Department of Pediatrics, University of Alabama at Birmingham, Birmingham, AL. Electronic address: asalas@peds.uab.edu.
² Department of Pediatrics, University of Alabama at Birmingham, Birmingham, AL.
³ Statistics and Epidemiology Unit, RTI International, Research Triangle Park, NC.
⁴ Department of Pediatrics, University of Iowa, Iowa City, IA.
⁵ Department of Pediatrics, Stanford University School of Medicine and Lucile Packard Children's Hospital, Palo Alto, CA.
⁶ Department of Pediatrics, Emory University and Children's Healthcare of Atlanta, Atlanta, GA.
⁷ Department of Pediatrics, Wayne State University, Detroit, MI.
⁸ Department of Pediatrics, Duke University, Durham, NC.
⁹ University of New Mexico Health Sciences Center, Albuquerque, NM.
¹⁰ National Institute of Child Health and Human Development, Bethesda, MD; Department of Global and Community Health, George Mason University, Fairfax, VA.

PMID: 34157349
PMCID: PMC8478787
DOI: 10.1016/j.jpeds.2021.06.026

Randomized Controlled Trial

Growth Rates of Infants Randomized to Continuous Positive Airway Pressure or Intubation After Extremely Preterm Birth

Ariel A Salas et al. J Pediatr. 2021 Oct.

. 2021 Oct:237:148-153.e3.

doi: 10.1016/j.jpeds.2021.06.026. Epub 2021 Jun 19.

Collaborators

Eunice Kennedy Shriver National Institute of Child Health and Human Development Neonatal Research Network:
Alan H Jobe, Michael S Caplan, Abbot R Laptook, William Oh, Betty R Vohr, Angelita M Hensman, Bonnie E Stephens, Barbara Alksninis, Dawn Andrews, Kristen Angela, Susan Barnett, Bill Cashore, Melinda Caskey, Kim Francis, Dan Gingras, Regina A Gargus, Katharine Johnson, Shabnam Lainwala, Theresa M Leach, Martha R Leonard, Sarah Lillie, Kalida Mehta, James R Moore, Lucy Noel, Suzy Ventura, Rachel V Walden, Victoria E Watson, Michele C Walsh, Avroy A Fanaroff, Nancy S Newman, Deanne E Wilson-Costello, Bonnie S Siner, Arlene Zadell, Julie DiFiore, Monika Bhola, Harriet G Friedman, Gulgun Yalcinkaya, Kurt Schibler, Edward F Donovan, Kimberly Yolton, Vivek Narendran, Kate Bridges, Barbara Alexander, Cathy Grisby, Marcia Worley Mersmann, Holly L Mincey, Jody Hessling, Teresa L Gratton, Ronald N Goldberg, C Michael Cotten, Ricki F Goldstein, Patricia Ashley, Kathy J Auten, Kimberley A Fisher, Katherine A Foy, Sharon F Freedman, Kathryn E Gustafson, Melody B Lohmeyer, William F Malcolm, David K Wallace, Barbara J Stoll, Susie Buchter, Anthony J Piazza, David P Carlton, Ira Adams-Chapman, Linda Black, Ann M Blackwelder, Sheena Carter, Elisabeth Dinkins, Sobha Fritz, Ellen C Hale, Amy K Hutchinson, Maureen Mulligan LaRossa, Gloria V Smikle, Stephanie Wilson Archer, James A Lemons, Anna M Dusick, Leslie D Wilson, Faithe Hamer, Ann B Cook, Dianne E Herron, Carolyn Lytle, Heike M Minnich, Mary Anne Berberich, Carol J Blaisdell, Dorothy B Gail, James P Kiley, W Kenneth Poole, Marie G Gantz, Jamie E Newman, Betty K Hastings, Jeanette O'Donnell Auman, Carolyn Petrie Huitema, James W Pickett 2nd, Dennis Wallace, Kristin M Zaterka-Baxter, David K Stevenson, Susan R Hintz, M Bethany Ball, Barbara Bentley, Elizabeth F Bruno, Alexis S Davis, Maria Elena DeAnda, Anne M DeBattista, Jean G Kohn, Melinda S Proud, Renee P Pyle, Nicholas H St John, Hali E Weiss, Ivan D Frantz 3rd, John M Fiascone, Elisabeth C McGowan, Anne Furey, Brenda L MacKinnon, Ellen Nylen, Ana Brussa, Cecelia Sibley, Namasivayam Ambalavanan, Monica V Collins, Shirley S Cosby, Myriam Peralta-Carcelen, Vivien A Phillips, Kirstin J Bailey, Fred J Biasini, Maria Hopkins, Kristen C Johnston, Sara Krzywanski, Kathleen G Nelson, Cryshelle S Patterson, Richard V Rector, Leslie Rodriguez, Amanda Soong, Sally Whitley, Sheree York, Neil N Finer, Maynard R Rasmussen, Paul R Wozniak, Yvonne E Vaucher, Wade Rich, Kathy Arnell, Rene Barbieri-Welge, Ayala Ben-Tall, Renee Bridge, Clarence Demetrio, Martha G Fuller, Elaine Ito, Meghan Lukasik, Deborah Pontillo, Donna Posin, Cheryl Runyan, James Wilkes, Paul Zlotnik, John A Widness, Jonathan M Klein, Tarah T Colaizy, Karen J Johnson, Michael J Acarregui, Diane L Eastman, Shahnaz Duara, Charles R Bauer, Ruth Everett-Thomas, Maria Calejo, Alexis N Diaz, Silvia M Frade Eguaras, Andrea Garcia, Kasey Hamlin-Smith, Michelle Harwood Berkowits, Sylvia Hiriart-Fajardo, Elaine O Mathews, Helina Pierre, Arielle Riguard, Alexandra Stroerger, Robin K Ohls, Janell Fuller, Julie Rohr, Conra Backstrom Lacy, Jean Lowe, Rebecca Montman, Nirupama Laroia, Dale L Phelps, Gary J Myers, Gary David Markowitz, Linda J Reubens, Diane Hust, Lisa Augostino, Julie Babish Johnson, Erica Burnell, Harris Gelbard, Rosemary L Jensen, Emily Kushner, Joan Merzbach, Jonathan Mink, Carlos Torres, David Wang, Kelley Yost, Pablo J Sánchez, Charles R Rosenfeld, Walid A Salhab, Roy J Heyne, Sally S Adams, James Allen, Laura Grau, Alicia Guzman, Gaynelle Hensley, Elizabeth T Heyne, Melissa H Lepps, Linda A Madden, Melissa Martin, Nancy A Miller, Janet S Morgan, Araceli Solis, Lizette E Torres, Catherine Twell Boatman, Diana M Vasil, Kerry Wilder, Kathleen A Kennedy, Jon E Tyson, Nora I Alaniz, Patricia W Evans, Beverly Foley Harris, Charles Green, Margarita Jiminez, Anna E Lis, Sarah Martin, Georgia E McDavid, Brenda H Morris, Margaret L Poundstone, Stacy Reddoch, Saba Siddiki, Patti L Pierce Tate, Laura L Whitely, Sharon L Wright, Bradley A Yoder, Roger G Faix, Shawna Baker, Karie Bird, Jill Burnett, Laura Cole, Karen A Osborne, Cynthia Spencer, Mike Steffens, Kimberlee Weaver-Lewis, Karen Zanetti, T Michael O'Shea, Robert G Dillard, Lisa K Washburn, Nancy J Peters, Barbara G Jackson, Korinne Chiu, Deborah Evans Allred, Donald J Goldstein, Raquel Halfond, Carroll Peterson, Ellen L Waldrep, Cherrie D Welch, Melissa Whalen Morris, Gail Wiley Hounshell, Athina Pappas, Beena G Sood, Rebecca Bara, Elizabeth Billian, Laura A Goldston, Mary Johnson, Richard A Ehrenkranz, Vineet Bhandari, Harris C Jacobs, Pat Cervone, Patricia Gettner, Monica Konstantino, JoAnn Poulsen, Janet Taft, Christine G Butler, Nancy Close, Walter Gilliam, Sheila Greisman, Elaine Romano, Joanne Williams

Affiliations

¹ Department of Pediatrics, University of Alabama at Birmingham, Birmingham, AL. Electronic address: asalas@peds.uab.edu.
² Department of Pediatrics, University of Alabama at Birmingham, Birmingham, AL.
³ Statistics and Epidemiology Unit, RTI International, Research Triangle Park, NC.
⁴ Department of Pediatrics, University of Iowa, Iowa City, IA.
⁵ Department of Pediatrics, Stanford University School of Medicine and Lucile Packard Children's Hospital, Palo Alto, CA.
⁶ Department of Pediatrics, Emory University and Children's Healthcare of Atlanta, Atlanta, GA.
⁷ Department of Pediatrics, Wayne State University, Detroit, MI.
⁸ Department of Pediatrics, Duke University, Durham, NC.
⁹ University of New Mexico Health Sciences Center, Albuquerque, NM.
¹⁰ National Institute of Child Health and Human Development, Bethesda, MD; Department of Global and Community Health, George Mason University, Fairfax, VA.

PMID: 34157349
PMCID: PMC8478787
DOI: 10.1016/j.jpeds.2021.06.026

Abstract

Objective: To evaluate the effects of early treatment with continuous positive airway pressure (CPAP) on nutritional intake and in-hospital growth rates of extremely preterm (EPT) infants.

Study design: EPT infants (24^0/7-27^6/7 weeks of gestation) enrolled in the Surfactant Positive Airway Pressure and Pulse Oximetry Trial (SUPPORT) were included. EPT infants who died before 36 weeks of postmenstrual age (PMA) were excluded. The growth rates from birth to 36 weeks of PMA and follow-up outcomes at 18-22 months corrected age of EPT infants randomized at birth to either early CPAP (intervention group) or early intubation for surfactant administration (control group) were analyzed.

Results: Growth data were analyzed for 810 of 1316 infants enrolled in SUPPORT (414 in the intervention group, 396 in the control group). The median gestational age was 26 weeks, and the mean birth weight was 839 g. Baseline characteristics, total nutritional intake, and in-hospital comorbidities were not significantly different between the 2 groups. In a regression model, growth rates between birth and 36 weeks of PMA, as well as growth rates during multiple intervals from birth to day 7, days 7-14, days 14-21, days 21-28, day 28 to 32 weeks PMA, and 32-36 weeks PMA did not differ between treatment groups. Independent of treatment group, higher growth rates from day 21 to day 28 were associated with a lower risk of having a Bayley-III cognitive score <85 at 18-22 months corrected age (P = .002).

Conclusions: EPT infants randomized to early CPAP did not have higher in-hospital growth rates than infants randomized to early intubation.

PubMed Disclaimer

Conflict of interest statement

The other authors declare no conflicts of interest.

Figures

See this image and copyright information in PMC

References

1. Stoll BJ, Hansen NI, Bell EF, Walsh MC, Carlo WA, Shankaran S, et al.Trends in Care Practices, Morbidity, and Mortality of Extremely Preterm Neonates, 1993–2012. JAMA. 2015;314:1039–51. - PMC - PubMed
1. Embleton ND, Morgan C, King C. Balancing the risks and benefits of parenteral nutrition for preterm infants: can we define the optimal composition? Arch Dis Child Fetal Neonatal Ed. 2015;100:F72–5. - PubMed
1. Martin CR, Brown YF, Ehrenkranz RA, O’Shea TM, Allred EN, Belfort MB, et al.Nutritional practices and growth velocity in the first month of life in extremely premature infants. Pediatrics. 2009;124:649–57. - PMC - PubMed
1. Embleton NE, Pang N, Cooke RJ. Postnatal malnutrition and growth retardation: an inevitable consequence of current recommendations in preterm infants? Pediatrics. 2001;107:270–3. - PubMed
1. Fenton TR, Anderson D, Groh-Wargo S, Hoyos A, Ehrenkranz RA, Senterre T. An Attempt to Standardize the Calculation of Growth Velocity of Preterm Infants-Evaluation of Practical Bedside Methods. J Pediatr. 2018;196:77–83. - PubMed

Publication types

Actions

MeSH terms

Actions
Actions
Actions
Actions
Actions
Actions
Actions
Actions
Actions
Actions
Actions
Actions
Actions
Actions
Actions
Actions

Substances

Actions

Grants and funding

LinkOut - more resources

Full Text Sources
Medical
- MedlinePlus Consumer Health Information
- MedlinePlus Health Information

Save citation to file

Email citation

Add to Collections

Add to My Bibliography

Your saved search

Create a file for external citation management software

Your RSS Feed

Growth Rates of Infants Randomized to Continuous Positive Airway Pressure or Intubation After Extremely Preterm Birth

Collaborators

Affiliations

Growth Rates of Infants Randomized to Continuous Positive Airway Pressure or Intubation After Extremely Preterm Birth

Authors

Collaborators

Affiliations

Abstract

Conflict of interest statement

Figures

References

Publication types

MeSH terms

Substances

Grants and funding

LinkOut - more resources

Full Text Sources

Medical