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. 2021 Oct:176:109825.
doi: 10.1016/j.apradiso.2021.109825. Epub 2021 Jun 12.

Cyclotron-produced 68Ga from enriched 68Zn foils

Jonathan Siikanen  1 , Emma Jussing  2 , Stefan Milton  2 , Carsten Steiger  3 , Johan Ulin  4 , Cathrine Jonsson  5 , Erik Samén  2 , Thuy A Tran  2
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Free article

Cyclotron-produced 68Ga from enriched 68Zn foils

Jonathan Siikanen et al. Appl Radiat Isot. 2021 Oct.
Free article

Abstract

The growing need and limited availability of generator produced 68Ga (T1/2 = 68 min) for PET has provided the impetus for alternative, high output, 68Ga production routes such as charge particle activation of enriched 68Zn using PET cyclotrons. The work presents a rapid production method for clinically useful 68Ga for radiolabeling. The focus is also to expand the production capacity of cyclotron solid target-produced 68Ga over generator produced and liquid solutions targets by using enriched 68Zn-foils that minimizes target preparation.

Keywords: Cyclotron produced (68)Ga; DOTA-Based AMA; Enriched (68)Zn foils; Solid target.

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