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Comment
. 2021 Dec;18(12):2583-2585.
doi: 10.1038/s41423-021-00723-7. Epub 2021 Jun 22.

New aspects of HSC mobilization for better therapeutic outcomes

Amiya K Patra  1
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Comment

New aspects of HSC mobilization for better therapeutic outcomes

Amiya K Patra. Cell Mol Immunol. 2021 Dec.
No abstract available

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Conflict of interest statement

The author declares no competing interests.

Figures

Fig. 1
Fig. 1
Schematic diagram showing nociceptive nerve-induced enhanced egress of HSCs from the BM to the blood circulation. The neurotransmitter CGRP is produced by nociceptive neurons and binds directly to HSCs through its receptor, increasing cAMP signaling in HSCs and ultimately promoting BM egress. Increased numbers of HSCs in the blood lead to better yields for transplantation and efficient hematopoietic reconstitution. This  effect has a critical influence on therapeutic outcome and patient survival.
See this image and copyright information in PMC

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