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Case Reports
. 2020 Jul-Dec;29(2):345-348.
doi: 10.4103/ipj.ipj_37_19. Epub 2021 Mar 15.

Linezolid-induced serotonin syndrome

Anish Shouan  1 , Rajeet Kumar  1 , Vivek Lal  2 , Sandeep Grover  1
Affiliations
Case Reports

Linezolid-induced serotonin syndrome

Anish Shouan et al. Ind Psychiatry J. 2020 Jul-Dec.

Abstract

Linezolid is an oxazolidinone antibiotic, which is a weak, reversible, nonselective monoamine oxidase A and B inhibitor; is known to increase serotonin levels, and has been implicated in the development of serotonin syndrome (SS). There is limited literature on the development of SS with linezolid, when used alone. In this report, we present the case of a 70-year-old female who developed features of SS while being treated with linezolid 600 mg twice daily for pneumonia. The SS in her case was managed with stoppage of linezolid, administration of cyproheptadine, and supportive measures.

Keywords: Delirium; linezolid; serotonin syndrome.

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Conflict of interest statement

There are no conflicts of interest.

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