Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
Case Reports
. 2021 Jan;31(1):209-211.
doi: 10.4314/ejhs.v31i1.24.

Gilbert Syndrome in a Young Ethiopian Man: First Case Report

Affiliations
Case Reports

Gilbert Syndrome in a Young Ethiopian Man: First Case Report

Amir Sultan et al. Ethiop J Health Sci. 2021 Jan.

Abstract

Background: Gilbert syndrome is a well-recognized condition causing unconjugated hyperbilirubinemia with otherwise normal transaminases and liver function tests.

Case: A 21 year old male patient presented with recurrent episodes of jaundice over four years. The episodes were preceded by stressful conditions and intercurrent illnesses. All laboratory prameters were normal except an unconjugated hyperbilirubinemia. A diagnosis of Gilbert syndrome was made after careful clinical evaluation.

Conclusion: Recognizing Gilbert syndrome has important clinical implicaitions by avoiding uncessary and expensive workup of patients with jaundice. Mangement entails avoiding stressful conditions and prolonged fasting.

Keywords: Ethiopia; Gilbert Syndrome; Hyperbillirubinemia; Jaundice; Liver.

PubMed Disclaimer

References

    1. Fretzayas A, Moustaki M, Liapi O, Karpathios T. Gilbert syndrome. European Journal of Pediatrics. 2011;171(1):11–15. Vol. 171. - PubMed
    1. Bosma PJ, Chowdhury JR, Bakker C, Gantla S, de Boer A, Oostra BA, et al. The genetic basis of the reduced expression of bilirubin udpglucuronosyltransferase 1 in gilbert's syndrome. N Engl J Med. 1995;333(18):1171–1175. - PubMed
    1. King D, Armstrong M. Overview of Gilbert's syndrome. Drug Ther Bull. 2019;57(2):27–31. - PubMed
    1. Kamal S, Abdelhakam S, Ghoraba D, Massoud Y, Aziz KA, Hassan H, et al. The frequency, clinical course, and health related quality of life in adults with Gilbert's syndrome: a longitudinal study. BMC Gastroenterol. 2019;19(1):22. - PMC - PubMed
    1. Borlak J, Thum T, Landt O, Erb K, Hermann R. Molecular diagnosis of a familial nonhemolytic hyperbilirubinemia (Gilbert's syndrome) in healthy subjects. Hepatology. 2000;32(4 I):792–795. - PubMed

Publication types

LinkOut - more resources