Conservative management of COVID-19 associated hypoxaemia

Alexander Supady^{1

2

3}, Philipp M Lepper⁴, Hendrik Bracht^{5

6}, Onnen Moerer⁷, Ralf M Muellenbach⁸, Guido Michels⁹, Mascha O Fiedler¹⁰, Armin Kalenka¹¹, Matthias Kochanek¹², Haitham Mutlak¹³, Guy Danziger⁴, Sebastian Muenz¹⁴, Dirk Lunz¹⁵, Sabrina Hoersch¹⁶, Dawid Staudacher^{1

2}, Tobias Wengenmayer^{1

2}, Viviane Zotzmann^{1

2}

Affiliations

¹ Dept of Medicine III (Interdisciplinary Medical Intensive Care), Medical Center, Faculty of Medicine, University of Freiburg, Freiburg im Breisgau, Germany.
² Dept of Cardiology and Angiology I, Heart Center, University of Freiburg, Freiburg im Breisgau, Germany.
³ Heidelberg Institute of Global Health, University of Heidelberg, Freiburg im Breisgau, Germany.
⁴ Dept of Internal Medicine V - Pneumology, Allergology and Critical Care Medicine, Saarland University Medical Center and University of Saarland, Homburg, Germany.
⁵ Dept of Anesthesiology and Intensive Care Medicine, University Hospital Ulm, Baden-Württemberg, Germany.
⁶ Dept of Emergency Medicine, University Hospital Ulm, Baden-Württemberg, Germany.
⁷ Dept of Anaesthesiology, University Medical Centre, Georg-August University Göttingen, Göttingen, Germany.
⁸ Dept of Anaesthesiology and Critical Care Medicine, Campus Kassel of the University of Southampton, Kassel, Germany.
⁹ Dept of Acute and Emergency Care, St Antonius Hospital Eschweiler, Eschweiler, Germany.
¹⁰ Dept of Anaesthesiology, Heidelberg University Hospital, Heidelberg, Germany.
¹¹ Dept of Anaesthesiology and Intensive Care Medicine, Kufstein District Hospital, Kufstein, Austria.
¹² First Dept of Internal Medicine, Center for Integrated Oncology Aachen Bonn Cologne Dusseldorf (CIO), University of Cologne, Cologne, Germany.
¹³ Dept of Anaesthesiology, Critical Care Medicine and Pain Medicine, SANA Klinikum Offenbach, Offenbach, Germany.
¹⁴ Dept of Internal Medicine - Cardiology, Pneumology, Angiology and Intensive Care Medicine, SLK-Hospital Heilbronn, Baden-Württemberg, Germany.
¹⁵ Dept of Anesthesiology and Intensive Care, University Hospital Regensburg, Regensburg, Germany.
¹⁶ Dept of Anesthesiology, Intensive Care and Pain Medicine, Saarland University Medical Center and University of Saarland, Homburg, Germany.

PMID: 34159186
PMCID: PMC8054352
DOI: 10.1183/23120541.00204-2021

Comment

Conservative management of COVID-19 associated hypoxaemia

Alexander Supady et al. ERJ Open Res. 2021.

. 2021 Jun 21;7(2):00204-2021.

doi: 10.1183/23120541.00204-2021. eCollection 2021 Apr.

Authors

Affiliations

¹ Dept of Medicine III (Interdisciplinary Medical Intensive Care), Medical Center, Faculty of Medicine, University of Freiburg, Freiburg im Breisgau, Germany.
² Dept of Cardiology and Angiology I, Heart Center, University of Freiburg, Freiburg im Breisgau, Germany.
³ Heidelberg Institute of Global Health, University of Heidelberg, Freiburg im Breisgau, Germany.
⁴ Dept of Internal Medicine V - Pneumology, Allergology and Critical Care Medicine, Saarland University Medical Center and University of Saarland, Homburg, Germany.
⁵ Dept of Anesthesiology and Intensive Care Medicine, University Hospital Ulm, Baden-Württemberg, Germany.
⁶ Dept of Emergency Medicine, University Hospital Ulm, Baden-Württemberg, Germany.
⁷ Dept of Anaesthesiology, University Medical Centre, Georg-August University Göttingen, Göttingen, Germany.
⁸ Dept of Anaesthesiology and Critical Care Medicine, Campus Kassel of the University of Southampton, Kassel, Germany.
⁹ Dept of Acute and Emergency Care, St Antonius Hospital Eschweiler, Eschweiler, Germany.
¹⁰ Dept of Anaesthesiology, Heidelberg University Hospital, Heidelberg, Germany.
¹¹ Dept of Anaesthesiology and Intensive Care Medicine, Kufstein District Hospital, Kufstein, Austria.
¹² First Dept of Internal Medicine, Center for Integrated Oncology Aachen Bonn Cologne Dusseldorf (CIO), University of Cologne, Cologne, Germany.
¹³ Dept of Anaesthesiology, Critical Care Medicine and Pain Medicine, SANA Klinikum Offenbach, Offenbach, Germany.
¹⁴ Dept of Internal Medicine - Cardiology, Pneumology, Angiology and Intensive Care Medicine, SLK-Hospital Heilbronn, Baden-Württemberg, Germany.
¹⁵ Dept of Anesthesiology and Intensive Care, University Hospital Regensburg, Regensburg, Germany.
¹⁶ Dept of Anesthesiology, Intensive Care and Pain Medicine, Saarland University Medical Center and University of Saarland, Homburg, Germany.

PMID: 34159186
PMCID: PMC8054352
DOI: 10.1183/23120541.00204-2021

Abstract

This correspondence argues that data presented previously cannot justify a novel approach for treating hypoxic patients with severe #COVID19 https://bit.ly/3dLaPlk.

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Conflict of interest statement

Conflict of interest: A. Supady reports a research grant from CytoSorbents to his institution, and lecture fees from CytoSorbents and Abiomed, not related to this work. Conflict of interest: P.M. Lepper has nothing to disclose. Conflict of interest: H. Bracht has nothing to disclose. Conflict of interest: O. Moerer has nothing to disclose. Conflict of interest: R.M. Muellenbach has nothing to disclose. Conflict of interest: G. Michels has nothing to disclose. Conflict of interest: M.O. Fiedler reports payment or honoraria for lectures, presentations, speaker bureaus, manuscript writing or educational events from GE and Löwenstein; and support for attending meetings and/or travel from Löwenstein. Conflict of interest: A. Kalenka has nothing to disclose. Conflict of interest: M. Kochanek has nothing to disclose. Conflict of interest: H. Mutlak has nothing to disclose. Conflict of interest: G. Danziger has nothing to disclose. Conflict of interest: S. Muenz has nothing to disclose. Conflict of interest: D. Lunz has nothing to disclose. Conflict of interest: S. Hoersch has nothing to disclose. Conflict of interest: D. Staudacher has nothing to disclose. Conflict of interest: T. Wengenmayer has nothing to disclose. Conflict of interest: V. Zotzmann has nothing to disclose.

Comment in

Conservative management of COVID-19 associated hypoxaemia.
Voshaar T, Stais P, Köhler D, Dellweg D. Voshaar T, et al. ERJ Open Res. 2021 Jun 21;7(2):00292-2021. doi: 10.1183/23120541.00292-2021. eCollection 2021 Apr. ERJ Open Res. 2021. PMID: 34164551 Free PMC article.

Comment on

Conservative management of COVID-19 associated hypoxaemia.
Windisch W, Kluge S, Bachmann M, Criée CP, Weber-Carstens S, Westhoff M, Karagiannidis C, Welte T. Windisch W, et al. ERJ Open Res. 2021 Apr 6;7(2):00113-2021. doi: 10.1183/23120541.00113-2021. eCollection 2021 Apr. ERJ Open Res. 2021. PMID: 33847696 Free PMC article.

References

1. Voshaar T, Stais P, Köhler D, et al. . Conservative management of COVID-19 associated hypoxaemia. ERJ Open Res 2021; 7: 00026-2021. doi:10.1183/23120541.00026-2021 - DOI - PMC - PubMed
1. Cummings MJ, Baldwin MR, Abrams D, et al. . Epidemiology, clinical course, and outcomes of critically ill adults with COVID-19 in New York City: a prospective cohort study. Lancet 2020; 395: 1763–1770. doi:10.1016/S0140-6736(20)31189-2 - DOI - PMC - PubMed
1. Grasselli G, Zangrillo A, Zanella A, et al. . Baseline Characteristics and Outcomes of 1591 Patients Infected With SARS-CoV-2 Admitted to ICUs of the Lombardy Region, Italy. JAMA 2020; 323: 1574–1581. doi:10.1001/jama.2020.5394 - DOI - PMC - PubMed
1. Gilbert-Kawai ET, Mitchell K, Martin D, et al. . Permissive hypoxaemia versus normoxaemia for mechanically ventilated critically ill patients. Cochrane Database Syst Rev 2014; 2014: CD009931. doi:10.1002/14651858.CD009931.pub2 - DOI - PMC - PubMed
1. Demir OM, Ryan M, Cirillo C, et al. . Impact and determinants of high-sensitivity cardiac troponin-T concentration in patients with COVID-19 admitted to critical care. Am J Cardiol 2021; 147: 129–136. doi:10.1016/j.amjcard.2021.01.037 - DOI - PMC - PubMed

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Conservative management of COVID-19 associated hypoxaemia

Affiliations

Conservative management of COVID-19 associated hypoxaemia

Authors

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Abstract

Conflict of interest statement

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