Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
. 2021 Dec;109(6):600-604.
doi: 10.1007/s00223-021-00875-8. Epub 2021 Jun 23.

MOF/Hip Fracture Ratio in a Belgian Cohort of Post-menopausal Women (FRISBEE): Potential Impact on the FRAX® Score

A Mugisha  1 , P Bergmann  2   3 , V Kinnard  2 , L Iconaru  4 , F Baleanu  4 , A Charles  5 , M Surquin  6   5 , S Rozenberg  7 , F Benoit  6 , J J Body  3   4   5
Affiliations

MOF/Hip Fracture Ratio in a Belgian Cohort of Post-menopausal Women (FRISBEE): Potential Impact on the FRAX® Score

A Mugisha et al. Calcif Tissue Int. 2021 Dec.

Abstract

The ratio between major osteoporotic fractures (MOFs) and hip fractures in the Belgian FRAX® tool to predict fractures is currently based on Swedish data. We determined these ratios in a prospective cohort of Belgian postmenopausal women. 3560 women, aged 60-85 years (70.1 ± 6.4 years), were included in a prospective study from 2007 to 2013 and surveyed yearly (FRISBEE). We analyzed the number of validated incident fractures until October 2020 by age and sites and compared the MOFs/hip ratios in this cohort with those from the Swedish databases. We registered 1336 fractures (mean follow-up of 9.1 years). The MOFs/hip ratios extracted from the FRISBEE cohort were 10.7 [95% CI: (5.6-20.5)], 6.4 [4.7-8.7], and 5.0 [3.9-6.5] for women of 60-69, 70-79, and 80-89 years old, respectively. These ratios were 1.7-1.8 times higher for all age groups than those from the Swedish data, which decreased from 6.5 (60-64 years group) down to 1.8 (85-89 age group). The overall MOFs/hip ratio in Frisbee was 6.0 [5.9-6.1], which was higher than any Swedish ratio between 65 and 85 years. Nevertheless, the decrease of the ratios with age paralleled that observed in Sweden. In this Brussels prospective cohort, MOFs/hip ratios were 1.7-1.8 times those observed in Sweden currently used for MOFs prediction in the Belgian FRAX® version. This discrepancy can greatly modify the estimation of the risk of MOFs, which is among the main criteria used to recommend a pharmacological treatment for osteoporosis in several countries.

Keywords: Aging; FRAX; Fracture prediction; Hip fracture; MOF; Osteoporosis.

PubMed Disclaimer

Comment in

References

    1. Kanis JA, Johansson H, Harvey NC, McCloskey EV (2019) A brief history of FRAX. Arch Osteoporos 13(1):118. https://doi.org/10.1007/s11657-018-0510-0 - DOI
    1. Kanis JA, Oden A, Johansson H, De Laet C, Brown J et al (2007) The use of clinical risk factors enhances the performance of BMD in the prediction of hip and osteoporotic fractures in men and women. Osteoporos Int 18:1033–1046. https://doi.org/10.1007/s00198-007-0343-y - DOI - PubMed
    1. Johansson H, Kanis JA, McCloskey OA et al (2011) A FRAX model for the assessment of fracture probability in Belgium. Osteoporos Int 22:453–461. https://doi.org/10.1007/s00198-010-1218-1 - DOI - PubMed
    1. Kanis JA, Oden A, Johnell O, Jonsson B, De Laet C, Dawson A (2000) The burden of osteoporotic fractures: a method for setting intervention thresholds. Osteoporos Int 12:417–427. https://doi.org/10.1007/s001980170112 - DOI
    1. Kanis JA, Johnell O, Oden A, Sembo I, Redlund-Johnell I, Dawson A, De Laet C, Jonsson B (2000) Long-term risk of osteoporotic fracture in Malmö. Osteoporos Int 11(8):669–674. https://doi.org/10.1007/s001980070064 - DOI - PubMed

Publication types

LinkOut - more resources