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Case Reports
. 2021 Oct;41(7):1668-1670.
doi: 10.1007/s10875-021-01085-5. Epub 2021 Jun 22.

Hematopoietic Stem Cell Transplantation Successfully Treats CD40LG Duplication

Di Sun  1 , Carole Le Coz  1 , Nancy Bunin  2 , Neil Romberg  3   4   5
Affiliations
Case Reports

Hematopoietic Stem Cell Transplantation Successfully Treats CD40LG Duplication

Di Sun et al. J Clin Immunol. 2021 Oct.
No abstract available

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References

    1. Blair PJ, Riley JL, Harlan DM, Abe R, Tadaki DK, Hoffmann SC, et al. Cd40 ligand (Cd154) triggers a short-term Cd4+ T cell activation response that results in secretion of immunomodulatory cytokines and apoptosis. J Exp Med. 2000;191:651–60. - DOI
    1. Higuchi T, Aiba Y, Nomura T, Matsuda J, Mochida K, Suzuki M, et al. Cutting edge: ectopic expression of CD40 ligand on B cells induces lupus-like autoimmune disease. J Immunol. 2002;168:9–12. - DOI
    1. Karnell JL, Rieder SA, Ettinger R, Kolbeck R. Targeting the CD40-CD40L pathway in autoimmune diseases: humoral immunity and beyond. Adv Drug Deliv Rev. 2019;141:92–103. - DOI
    1. Le Coz C, Trofa M, Syrett CM, Martin A, Jyonouchi H, Jyonouchi S, et al. CD40LG duplication-associated autoimmune disease is silenced by nonrandom X-chromosome inactivation. J Allergy Clin Immunol. 2018;141:2308-2311.e7. - DOI
    1. Dunn RJ, Luedecker CJ, Haugen HS, Clegg CH, Farr AG. Thymic overexpression of CD40 ligand disrupts normal thymic epithelial organization. J Histochem Cytochem. 1997;45:129–41. - DOI

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