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. 2021 Dec;25(12):3160-3169.
doi: 10.1007/s11605-021-04925-2. Epub 2021 Jun 22.

Intraoperative (Contrast-Enhanced) Ultrasound Has the Highest Diagnostic Accuracy of Any Imaging Modality in Resection of Colorectal Liver Metastases

Gregor A Stavrou  1   2 , Axel Stang  3   4 , Dimitri A Raptis  5 , Erik Schadde  6   7   8 , Martin Zeile  9 , Roland Brüning  10 , Kim C Wagner  11 , Tessa M Huber  11 , Karl J Oldhafer  3   11
Affiliations

Intraoperative (Contrast-Enhanced) Ultrasound Has the Highest Diagnostic Accuracy of Any Imaging Modality in Resection of Colorectal Liver Metastases

Gregor A Stavrou et al. J Gastrointest Surg. 2021 Dec.

Abstract

Aim: Defining sensitivity, specificity, diagnostic accuracy for detection of colorectal liver metastases in imaging compared to intraoperative assessment. Defining a cutoff, where accuracy of detection is impaired.

Methods: Prospective single-institution clinical trial (clinicaltrials.gov: NCT01522209). Patients underwent CEUS, MDCT, and 3 Tesla EOB-MRI within 2 weeks preoperatively. Intraoperative palpation, IOUS, and CEIOUS were performed. A patient and lesion-based database was analyzed for accuracy of detection of CEUS, CT, MRI, and Palp/IOUS/CEIOUS combined read. Histology was standard of reference.

Results: Forty-seven high tumor load (mean 5, 4 lesions) patients were analyzed. Histopathology confirmed 264 lesions (245 malignant: 19 benign). Accuracy for detection of all lesions: CEUS 63%, CT 71%, MRI 92%, and PALP/IOUS/CEIOUS 98%. ROC analysis for lesion size showed severe impairment of accuracy in lesion detection smaller than 5mm. Intraoperative imaging was not impaired by lesion size. Patient-based analysis revealed a change of resection plan after IOUS/CEIOUS in 35% of patients.

Conclusion: At 5-mm lesion size, preoperative imaging shows a drop in accuracy of detection. In patients with multiple lesions, addition of MRI to MDCT seems useful. Accuracy of intraoperative ultrasound is not impacted by lesion size and should be mandatory. CEIOUS can improve intraoperative decision-making.

Trial registration: Study registered with clinicaltrials.gov : NCT01522209.

Keywords: Accuracy; CEIOUS; Colorectal; IOUS; Imaging; Liver metastasis; Sensitivity; Specificity.

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