Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
. 2021 Sep;36(9):2199-2200.
doi: 10.1002/mds.28665. Epub 2021 Jun 22.

Potential PINK1 Founder Effect in Polynesia Causing Early-Onset Parkinson's Disease

Shilpan G Patel #  1 , Christina M Buchanan #  1 , Eoin Mulroy  1   2 , Mark Simpson  1 , Hannah A Reid  3 , Kylie M Drake  3 , Marilyn E Merriman  4 , Amanda Phipps-Green  4 , Murray Cadzow  4 , Tony R Merriman  4   5 , Neil E Anderson  1 , Nicholas Child  1 , P Alan Barber  1 , Richard H Roxburgh  1   6
Affiliations

Potential PINK1 Founder Effect in Polynesia Causing Early-Onset Parkinson's Disease

Shilpan G Patel et al. Mov Disord. 2021 Sep.
No abstract available

Keywords: PINK1; Polynesia; dystonia; early onset Parkinson's disease; recessive genetic conditions.

PubMed Disclaimer

References

    1. Alcalay RN, Caccappolo E, Mejia-Santana H, et al. Frequency of known mutations in early-onset Parkinson disease: implication for genetic counseling: the consortium on risk for early onset Parkinson disease study. Arch Neurol 2010;67(9):1116-1122.
    1. Rogaeva E, Johnson J, Lang AE, et al. Analysis of the PINK1 gene in a large cohort of cases with Parkinson disease. Arch Neurol 2004;61(12):1898-1904.
    1. Steele JC, Guella I, Szu-Tu C, et al. Defining neurodegeneration on Guam by targeted genomic sequencing. Ann Neurol 2015;77(3):458-468.
    1. Tan AH, Lohmann K, Tay YW, et al. PINK1 p.Leu347Pro mutations in Malays: prevalence and illustrative cases. Parkinsonism Relat Disord 2020;79:34-39.
    1. Matisoo-Smith E. Ancient DNA and the human settlement of the Pacific: a review. J Hum Evol 2015;79:93-104.

Publication types

Substances

LinkOut - more resources