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Comment
. 2021 Jun 23;9(1):113.
doi: 10.1186/s40478-021-01215-5.

Autopsy findings of previously described case of diffuse intrinsic pontine glioma-like tumor with EZHIP expression and molecular features of PFA ependymoma

Murad Alturkustani  1   2 , Jennifer A Cotter  3   4 , Roshan Mahabir  4 , Debra Hawes  3   4 , Carl Koschmann  5   6 , Sriram Venneti  7   6 , Alexander R Judkins  3   4 , Linda J Szymanski  3   4
Affiliations
Comment

Autopsy findings of previously described case of diffuse intrinsic pontine glioma-like tumor with EZHIP expression and molecular features of PFA ependymoma

Murad Alturkustani et al. Acta Neuropathol Commun. .
No abstract available

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Conflict of interest statement

The authors declare that they have no competing interests.

Figures

Fig. 1
Fig. 1
Autopsy findings. a Lobulated brainstem tumor. b Pons with solid and infiltrative tumor growth. c. Leptomeningeal spread (arrow) at the level of mamillary bodies and infiltrative neoplastic cells in the ventral thalamus as indicated by the square (see f). d, e. Solid well-circumscribed nodule of ependymal differentiation with true ependymal rosettes in the pons (H&E, D:40× , E:600×). f. Infiltrative tumor involving the thalamus, H&E, 400× . g Infiltrative tumor involving the cerebellar dentate nucleus, H&E, 100× . h EMA staining in solid and infiltrative components, 200× . i. H3K27me3 staining is lost in the infiltrative neoplastic cells while retained in the entrapped neurons and endothelial cells, 400× .j. EZHIP (CXorf67) staining highlights the infiltrative component while negative in the endothelial cells and the entrapped neurons 400×
See this image and copyright information in PMC

Comment on

References

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