Targeting calcium-related mechanotransduction in early OA
- PMID: 34163062
- DOI: 10.1038/s41584-021-00649-4
Targeting calcium-related mechanotransduction in early OA
Comment on
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A dysfunctional TRPV4-GSK3β pathway prevents osteoarthritic chondrocytes from sensing changes in extracellular matrix viscoelasticity.Nat Biomed Eng. 2021 Dec;5(12):1472-1484. doi: 10.1038/s41551-021-00691-3. Epub 2021 Mar 11. Nat Biomed Eng. 2021. PMID: 33707778 Free PMC article.
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Inflammatory signaling sensitizes Piezo1 mechanotransduction in articular chondrocytes as a pathogenic feed-forward mechanism in osteoarthritis.Proc Natl Acad Sci U S A. 2021 Mar 30;118(13):e2001611118. doi: 10.1073/pnas.2001611118. Proc Natl Acad Sci U S A. 2021. PMID: 33758095 Free PMC article.
References
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- Lee, W. et al. Inflammatory signaling sensitizes Piezo1 mechanotransduction in articular chondrocytes as a pathogenic feed-forward mechanism in osteoarthritis. Proc. Natl Acad. Sci. USA 118, e2001611118 (2021). - DOI
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- Agarwal, P. et al. A dysfunctional TRPV4–GSK3β pathway prevents osteoarthritic chondrocytes from sensing changes in extracellular matrix viscoelasticity. Nat. Biomed. Eng. https://doi.org/10.1038/s41551-021-00691-3 (2021). - DOI - PubMed
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- Grodzinsky, A. J. et al. Cartilage tissue remodeling in response to mechanical forces. Annu. Rev. Biomed. Eng. 2, 691–713 (2000). - DOI
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- Bartell, L. R. et al. Mitoprotective therapy prevents rapid, strain-dependent mitochondrial dysfunction after articular cartilage injury. J. Orthop. Res. 38, 1257–1267 (2020). - DOI
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- Delco, M. L. et al. Mitochondrial dysfunction is an acute response of articular chondrocytes to mechanical injury. J. Orthop. Res. 36, 739–750 (2018). - DOI
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