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Review
. 2021 Jun 7:15:563807.
doi: 10.3389/fnhum.2021.563807. eCollection 2021.

Altered Sleep-Related Consolidation and Neurocognitive Comorbidity in CECTS

Victoria Georgopoulou  1   2 , Karen Spruyt  3 , Kyriakos Garganis  4 , Mary H Kosmidis  5
Affiliations
Review

Altered Sleep-Related Consolidation and Neurocognitive Comorbidity in CECTS

Victoria Georgopoulou et al. Front Hum Neurosci. .

Abstract

Our aim is to use neurophysiological sleep-related consolidation (SRC) phenomena to identify putative pathophysiological mechanisms in CECTS linked to diffuse neurocognitive deficits. We argue that there are numerous studies on the association between seizure aspects and neurocognitive functioning but not as many on interictal variables and neurocognitive deficits. We suggest two additional foci. First, the interictal presentation in CECTS and second, neuronal oscillations involved in SRC processes. Existing data on mechanisms through which interictal epileptiform spikes (IES) impact upon SRC indicate that they have the potential to: (a) perturb cross-regional coupling of neuronal oscillations, (b) mimic consolidation processes, (c) alter the precision of the spatiotemporal coupling of oscillations, and (d) variably impact upon SRC performance. Sleep spindles merit systematic study in CECTS in order to clarify: (a) the state of the slow oscillations (SOs) with which they coordinate, (b) the precision of slow oscillation-spindle coupling, and (c) whether their developmental trajectories differ from those of healthy children. We subsequently review studies on the associations between IES load during NREM sleep and SRC performance in childhood epilepsy. We then use sleep consolidation neurophysiological processes and their interplay with IES to help clarify the diffuse neurocognitive deficits that have been empirically documented in CECTS. We claim that studying SRC in CECTS will help to clarify pathophysiological mechanisms toward diverse neurocognitive deficits. Future developments could include close links between the fields of epilepsy and sleep, as well as new therapeutic neurostimulation targets. At the clinical level, children diagnosed with CECTS could benefit from close monitoring with respect to epilepsy, sleep and neurocognitive functions.

Keywords: active system consolidation; memory; neuronal oscillations; neuroplasticity; sleep electrophysiology.

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Conflict of interest statement

The authors declare that the research was conducted in the absence of any commercial or financial relationships that could be construed as a potential conflict of interest. The handling editor declared a past co-authorship with one of the authors KG.

References

    1. Bathory E., Tomopoulos S. (2017). Sleep regulation, physiology and development, sleep duration and patterns, and sleep hygiene in infants, toddlers, and preschool-age children. Curr. Probl. Pediatr. Adolesc. Health Care 47 29–42. 10.1016/j.cppeds.2016.12.001 - DOI - PubMed
    1. Bove A., Culebras A., Moore J. T., Westlake R. E. (1994). Relationship between sleep spindles and hypersomnia. Sleep 17 449–455. 10.1093/sleep/17.5.449 - DOI - PubMed
    1. Bower M. R., Kucewicz M. T., St. Louis E. K., Meyer F. B., Marsh W. R., Stead M., et al. (2017). Reactivation of seizure-related changes to interictal spike shape and synchrony during postseizure sleep in patients. Epilepsia 58 94–104. 10.1111/epi.13614 - DOI - PMC - PubMed
    1. Buzsáki G. (1996). The hippocampo-neocortical dialogue. Cereb. Cortex 6 81–92. - PubMed
    1. Cellini N. (2017). Memory consolidation in sleep disorders. Sleep Med. Rev. 35 101–112. 10.1016/j.smrv.2016.09.003 - DOI - PubMed