Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
. 1988 Jul;253(1):39-45.
doi: 10.1007/BF00221737.

Morphological studies on endocytosis of chondroitin sulphate proteoglycan by rat liver endothelial cells

B Smedsrød  1 , M Malmgren, J Ericsson, T C Laurent
Affiliations

Morphological studies on endocytosis of chondroitin sulphate proteoglycan by rat liver endothelial cells

B Smedsrød et al. Cell Tissue Res. 1988 Jul.

Abstract

Endocytosis via the hyaluronic acid/chondroitin sulphate receptor of rat liver endothelial cells was studied ultrastructurally, by use of a probe consisting of chondroitin sulphate proteoglycan attached to 15-nm gold particles. The probe bound to the surface of the cells exclusively in coated regions of the plasma membrane. Internalization at 37 degrees C took place in less than one minute during which time interval the bound probe was transferred to coated vesicles. Further transfer to lysosomes was delayed in association with an accumulation of probes in a prelysosomal compartment consisting of large vacuoles in which probes lined the inner aspect of the membrane. Transport to lysosomes occurred only after a lag phase of at least 40-60 min at 37 degrees C.

PubMed Disclaimer

References

    1. Eur J Cell Biol. 1984 May;34(1):110-7 - PubMed
    1. Cell. 1983 Jan;32(1):277-87 - PubMed
    1. Biochem J. 1985 Jun 1;228(2):415-24 - PubMed
    1. Cell Tissue Res. 1985;241(3):639-49 - PubMed
    1. J Cell Biol. 1977 Feb;72(2):441-55 - PubMed

Publication types