Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
Review
. 2021 Jun 7;9(6):23259671211015667.
doi: 10.1177/23259671211015667. eCollection 2021 Jun.

Biologic Association Annual Summit: 2020 Report

Rachel M Frank  1 , Seth L Sherman  2 , Jorge Chahla  3 , Jason L Dragoo  1 , Bert Mandelbaum  4 ; Members of the Biologic Association; Adam W Anz  1   2   3   4 , James P Bradley  1   2   3   4 , Constance R Chu  1   2   3   4 , Brian J Cole  1   2   3   4 , Jack Farr  1   2   3   4 , David C Flanigan  1   2   3   4 , Andreas H Gomoll  1   2   3   4 , Joanne Halbrecht  1   2   3   4 , Kay Horsch  1   2   3   4 , Christian Lattermann  1   2   3   4 , Philipp Leucht  1   2   3   4 , William J Maloney  1   2   3   4 , Louis F McIntyre  1   2   3   4 , Iain Murray  1   2   3   4 , George F Muschler  1   2   3   4 , Norimasa Nakamura  1   2   3   4 , Nicolas S Piuzzi  1   2   3   4 , Scott A Rodeo  1   2   3   4 , Daniel B F Saris  1   2   3   4 , William O Shaffer  1   2   3   4 , Shane A Shapiro  1   2   3   4 , Kurt P Spindler  1   2   3   4 , Matthias Steinwachs  1   2   3   4 , John M Tokish  1   2   3   4 , C Thomas Vangsness  1   2   3   4 , John Tracy Watson  1   2   3   4 , Adam B Yanke  1   2   3   4 , Kenneth R Zaslav  1   2   3   4
Affiliations
Review

Biologic Association Annual Summit: 2020 Report

Rachel M Frank et al. Orthop J Sports Med. .

Abstract

Interest and research in biologic approaches for tissue healing are exponentially growing for a variety of musculoskeletal conditions. The recent hype concerning musculoskeletal biological therapies (including viscosupplementation, platelet-rich plasma, and cellular therapies, or "stem cells") is driven by several factors, including demand by patients promising regenerative evidence supported by substantial basic and translational work, as well as commercial endeavors that complicate the scientific and lay understanding of biological therapy outcomes. While significant improvements have been made in the field, further basic and preclinical research and well-designed randomized clinical trials are needed to better elucidate the optimal indications, processing techniques, delivery, and outcome assessment. Furthermore, biologic treatments may have potential devastating complications when proper methods or techniques are ignored. For these reasons, an association comprising several scientific societies, named the Biologic Association (BA), was created to foster coordinated efforts and speak with a unified voice, advocating for the responsible use of biologics in the musculoskeletal environment in clinical practice, spearheading the development of standards for treatment and outcomes assessment, and reporting on the safety and efficacy of biologic interventions. This article will introduce the BA and its purpose, provide a summary of the 2020 first annual Biologic Association Summit, and outline the future strategic plan for the BA.

Keywords: Biologic Association; biologics; orthobiologics; osteoarthritis; platelet-rich plasma; stem cells.

PubMed Disclaimer

Conflict of interest statement

One or more of the authors has declared a potential conflict of interest or source of funding: see supplemental material for details. AOSSM checks author disclosures against the Open Payments Database (OPD). AOSSM has not conducted an independent investigation on the OPD and disclaims any liability or responsibility relating thereto.

References

    1. Chu CR, Rodeo S, Bhutani N, et al. Optimizing clinical use of biologics in orthopaedic surgery. J Am Acad Orthop Surg. 2019;27(2):e50–e63. - PMC - PubMed
    1. Doral MN, Tandoğan RN, Mann G, Verdonk R. Sports Injuries: Prevention, Diagnosis, Treatment and Rehabilitation. Springer; 2011.
    1. Goodman SB, Yao Z, Keeney M, Yang F. The future of biologic coatings for orthopaedic implants. Biomaterials. 2013;34(13):3174–3183. - PMC - PubMed
    1. LaPrade RF, Geeslin AG, Murray IR, et al. Biologic Treatments for Sports Injuries II Think Tank—current concepts, future research, and barriers to advancement, part 1: biologics overview, ligament injury, tendinopathy. Am J Sports Med. 2016;44(12):3270–3283. - PubMed
    1. Murray I, Chahla J, Frank R, et al. Rogue stem cell clinics. Bone Joint J. 2020;102(2):148–154. - PMC - PubMed

LinkOut - more resources