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Review
. 2022 Mar;9(2):942-949.
doi: 10.1002/nop2.922. Epub 2021 Jun 24.

Treating the most vulnerable: A discursive review of experimental pain in Alzheimer's disease

Wm Larkin Iversen  1 , Ronald L Cowan  2 , Sebastian Atalla  1 , Sydney S Englehart  1 , Tanya R Gure  3 , Karen O Moss  1 , Claire M Ryan  4 , Douglas W Scharre  5 , Kathy D Wright  1 , Todd B Monroe  1
Affiliations
Review

Treating the most vulnerable: A discursive review of experimental pain in Alzheimer's disease

Wm Larkin Iversen et al. Nurs Open. 2022 Mar.

Abstract

Aim: The purpose of this manuscript is to summarize research on how experimental pain is experienced by adults with Alzheimer's disease (AD) and to translate results into implications for nurses.

Design: This discursive review synthesizes the results of three previous research studies exploring experimental pain in adults with AD.

Methods: Using a series of fictional clinical vignettes, the authors discuss how the results from three previous papers using acute experimental pain can potentially be translated into clinical practice. The authors also introduce the reader to the concept of research-related psychophysics using introductory definitions and concepts with the impetus to encourage other nurses to consider this research methodology.

Results: Pain characteristics in AD that differ from cognitively intact controls must be explored to properly address pain in this population. Nurses are well positioned to address these issues in order to provide a high quality of care to adults with AD.

Keywords: dementia; pain; psychophysics.

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Conflict of interest statement

The authors have no conflicts of interest to report.

References

    1. Ahn, H. , & Horgas, A. (2013). The relationship between pain and disruptive behaviors in nursing home resident with dementia. BMC Geriatrics, 13(1), 14. 10.1186/1471-2318-13-14 - DOI - PMC - PubMed
    1. Bajic, V. P. , Essack, M. , Zivkovic, L. , Stewart, A. , Zafirovic, S. , Bajic, V. B. , Gojobori, T. , Isenovic, E. , & Spremo‐Potparevic, B. (2020). The X files: “The mystery of X chromosome instability in Alzheimer’s disease”. Frontiers in Genetics, 10, 1368. 10.3389/fgene.2019.01368 - DOI - PMC - PubMed
    1. Basbaum, A. I. , Bautista, D. M. , Scherrer, G. , & Julius, D. (2009). Cellular and Molecular Mechanisms of Pain. Cell, 139, 267–284. 10.1016/j.cell.2009.09.028 - DOI - PMC - PubMed
    1. Beach, P. A. , Huck, J. T. , Miranda, M. M. , Foley, K. T. , & Bozoki, A. C. (2016). Effects of Alzheimer disease on the facial expression of pain. Clinical Journal of Pain, 32(6), 478–487. 10.1097/AJP.0000000000000302 - DOI - PubMed
    1. Benedetti, F. , Arduino, C. , Vighetti, S. , Asteggiano, G. , Tarenzi, L. , & Rainero, I. (2004). Pain reactivity in Alzheimer patients with different degrees of cognitive impairment and brain electrical activity deterioration. Pain, 111(1–2), 22–29. 10.1016/j.pain.2004.05.015 - DOI - PubMed

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