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Comment
. 2021 Aug 2;131(15):e152474.
doi: 10.1172/JCI152474.

Association of rare predicted loss-of-function variants of influenza-related type I IFN genes with critical COVID-19 pneumonia

Qian Zhang  1 , Aurélie Cobat  1   2   3 , Paul Bastard  2   3 , Luigi D Notarangelo  4   5 , Helen C Su  4   5 , Laurent Abel  1   2   3 , Jean-Laurent Casanova  1   2   3   6   7 ; COVID Human Genetic Effort (CHGE)
Affiliations
Comment

Association of rare predicted loss-of-function variants of influenza-related type I IFN genes with critical COVID-19 pneumonia

Qian Zhang et al. J Clin Invest. .
No abstract available

Keywords: Genetic variation; Infectious disease.

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Conflict of interest statement

Conflict of interest: The authors have declared that no conflict of interest exists.

Comment in

Comment on

  • Rare loss-of-function variants in type I IFN immunity genes are not associated with severe COVID-19.
    Povysil G, Butler-Laporte G, Shang N, Wang C, Khan A, Alaamery M, Nakanishi T, Zhou S, Forgetta V, Eveleigh RJ, Bourgey M, Aziz N, Jones SJ, Knoppers B, Scherer SW, Strug LJ, Lepage P, Ragoussis J, Bourque G, Alghamdi J, Aljawini N, Albes N, Al-Afghani HM, Alghamdi B, Almutairi MS, Mahmoud ES, Abu-Safieh L, El Bardisy H, Harthi FSA, Alshareef A, Suliman BA, Alqahtani SA, Almalik A, Alrashed MM, Massadeh S, Mooser V, Lathrop M, Fawzy M, Arabi YM, Mbarek H, Saad C, Al-Muftah W, Jung J, Mangul S, Badji R, Thani AA, Ismail SI, Gharavi AG, Abedalthagafi MS, Richards JB, Goldstein DB, Kiryluk K. Povysil G, et al. J Clin Invest. 2021 Jul 15;131(14):e147834. doi: 10.1172/JCI147834. J Clin Invest. 2021. PMID: 34043590 Free PMC article.

References

    1. Povysil G, et al. Rare loss-of-function variants in type I IFN immunity genes are not associated with severe COVID-19. J Clin Invest. 2021;131(14):e147834. doi: 10.1172/JCI147834. - DOI - PMC - PubMed
    1. Zhang Q, et al. Inborn errors of type I IFN immunity in patients with life-threatening COVID-19. Science. 2020;370(6515):eabd4570. doi: 10.1126/science.abd4570. - DOI - PMC - PubMed
    1. WHO Working Group on the Clinical Characterisation and Management of COVID-19 infection. A minimal common outcome measure set for COVID-19 clinical research. Lancet Infect Dis. 2020;20(8):e192–e197. doi: 10.1016/S1473-3099(20)30483-7. - DOI - PMC - PubMed
    1. Bastard P, et al. Autoantibodies against type I IFNs in patients with life-threatening COVID-19. Science. 2020;370(6515):eabd4585. doi: 10.1126/science.abd4585. - DOI - PMC - PubMed

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