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. 2021 Sep 16;138(11):992-996.
doi: 10.1182/blood.2021012479.

The use of IV immunoglobulin in the treatment of vaccine-induced immune thrombotic thrombocytopenia

Günalp Uzun  1 , Karina Althaus  1   2 , Anurag Singh  2 , Peter Möller  3 , Ulf Ziemann  4 , Annerose Mengel  4 , Peter Rosenberger  5 , Martina Guthoff  6 , Gabor C Petzold  7 , Jens Müller  8 , Martin Büchsel  9 , Katharina Feil  4 , Hans Henkes  10 , Nils Heyne  6 , Matthias Maschke  11 , Caroline Limpach  11 , Simon Nagel  12 , Ulrich J Sachs  13 , Falko Fend  14 , Tamam Bakchoul  1   2
Affiliations

The use of IV immunoglobulin in the treatment of vaccine-induced immune thrombotic thrombocytopenia

Günalp Uzun et al. Blood. .
No abstract available

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Figures

Figure 1.
Figure 1.
Individual course of the platelet counts and therapies. Five cases (A-E) of VITT after severe acute respiratory syndrome coronavirus 2 vaccination were identified. Patients were treated with nonheparin anticoagulation (argatroban, green blocks; danaparoid, lavender blocks; direct oral anticoagulants, orange blocks) combined with IVIG. Patients receiving therapeutic anticoagulation with platelet counts below 50 × 109/L (dashed line) were considered to be at enhanced risk for major hemorrhage. CSVT, cerebral sinus vein thrombosis; DVT, deep vein thrombosis; PE, pulmonary embolism; PLT, platelet.
Figure 2.
Figure 2.
Effect of IVIG therapy on PLT count and procoagulant platelets. Platelet count increment (A) and procoagulant platelets after IVIG therapy (B-C). Procoagulant platelets (CD62P/Phosphatidylserine [PS]+) were analyzed in patients before and after IVIG therapy via Annexin V-FITC and CD62p-APC antibody staining. Where indicated, PLTs were pretreated with PF4 (C). Data are presented as fold increase compared with healthy control. ns, not significant. *P < .05. The number of sera tested is reported in each graphic.
See this image and copyright information in PMC

Comment in

  • Cooling down VITT with IVIG.
    Lentz SR. Lentz SR. Blood. 2021 Sep 16;138(11):921-922. doi: 10.1182/blood.2021012819. Blood. 2021. PMID: 34529019 Free PMC article. No abstract available.

References

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