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. 1988 Jul;7(7):2035-41.
doi: 10.1002/j.1460-2075.1988.tb03043.x.

Four classes of mRNA are expressed from the mouse int-2 gene, a member of the FGF gene family

S L Mansour  1 , G R Martin
Affiliations

Four classes of mRNA are expressed from the mouse int-2 gene, a member of the FGF gene family

S L Mansour et al. EMBO J. 1988 Jul.

Abstract

Mouse embryos at 7.5 days of gestation and endodermal cells derived from embryonal carcinoma cells each express four int-2 mRNAs of similar size and relative abundance. To determine their structure and coding potential, we prepared a cDNA library from endoderm mRNA and isolated several int-2 cDNAs. Structural analysis of these cDNAs combined with Northern blot hybridization and primer extension analyses of int-2 mRNA revealed that the differences between the mRNAs are generated through the use of two alternate transcriptional start sites and two alternate polyadenylation sites. All four mRNAs share a common core sequence that encodes a protein with amino acid similarity to fibroblast growth factor.

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References

    1. Proc Natl Acad Sci U S A. 1972 Jun;69(6):1408-12 - PubMed
    1. EMBO J. 1986 May;5(5):919-24 - PubMed
    1. Dev Biol. 1977 Dec;61(2):230-44 - PubMed
    1. Science. 1986 Aug 1;233(4763):541-5 - PubMed
    1. Science. 1986 Aug 1;233(4763):545-8 - PubMed

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