A single-cell atlas of fibroblasts: one size does not fit all

Jie Wang^{1

2}, Florian Rieder^{3

4}

Affiliations

¹ Henan Key Laboratory of Immunology and Targeted Drug, Xinxiang Medical University, Xinxiang, Henan Province, China.
² Department of Inflammation and Immunity, Lerner Research Institute, Cleveland Clinic Foundation, Cleveland, OH, USA.
³ Department of Inflammation and Immunity, Lerner Research Institute, Cleveland Clinic Foundation, Cleveland, OH, USA. riederf@ccf.org.
⁴ Department of Gastroenterology, Hepatology and Nutrition, Digestive Diseases and Surgery Institute, Cleveland Clinic Foundation, Cleveland, OH, USA. riederf@ccf.org.

Comment

Jie Wang et al. Nat Rev Gastroenterol Hepatol. 2021 Sep.

. 2021 Sep;18(9):595-596.

doi: 10.1038/s41575-021-00482-w. Epub 2021 Jun 24.

Jie Wang^{1

2}, Florian Rieder^{3

4}

¹ Henan Key Laboratory of Immunology and Targeted Drug, Xinxiang Medical University, Xinxiang, Henan Province, China.
² Department of Inflammation and Immunity, Lerner Research Institute, Cleveland Clinic Foundation, Cleveland, OH, USA.
³ Department of Inflammation and Immunity, Lerner Research Institute, Cleveland Clinic Foundation, Cleveland, OH, USA. riederf@ccf.org.
⁴ Department of Gastroenterology, Hepatology and Nutrition, Digestive Diseases and Surgery Institute, Cleveland Clinic Foundation, Cleveland, OH, USA. riederf@ccf.org.

No abstract available

Comment on

Cross-tissue organization of the fibroblast lineage.
Buechler MB, Pradhan RN, Krishnamurty AT, Cox C, Calviello AK, Wang AW, Yang YA, Tam L, Caothien R, Roose-Girma M, Modrusan Z, Arron JR, Bourgon R, Müller S, Turley SJ. Buechler MB, et al. Nature. 2021 May;593(7860):575-579. doi: 10.1038/s41586-021-03549-5. Epub 2021 May 12. Nature. 2021. PMID: 33981032

1. Kulkarni, A., Anderson, A. G., Merullo, D. P. & Konopka, G. Beyond bulk: a review of single cell transcriptomics methodologies and applications. Curr. Opin. Biotechnol. 58, 129–136 (2019). - DOI
1. Wang, J. et al. Novel mechanisms and clinical trial endpoints in intestinal fibrosis. Immunol. Rev. https://doi.org/10.1111/imr.12974 (2021). - DOI - PubMed
1. Lynch, M. D. & Watt, F. M. Fibroblast heterogeneity: implications for human disease. J. Clin. Invest. 128, 26–35 (2018). - DOI
1. Guerrero-Juarez, C. F. et al. Single-cell analysis reveals fibroblast heterogeneity and myeloid-derived adipocyte progenitors in murine skin wounds. Nat. Commun. 10, 650 (2019). - DOI
1. Buechler, M. B. et al. Cross-tissue organization of the fibroblast lineage. Nature 593, 575–579 (2021). - DOI