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. 1988 Sep 15;44(9):762-4.
doi: 10.1007/BF01959156.

Enantiomeric cannabinoids: stereospecificity of psychotropic activity

R Mechoulam  1 , J J Feigenbaum, N Lander, M Segal, T U Järbe, A J Hiltunen, P Consroe
Affiliations

Enantiomeric cannabinoids: stereospecificity of psychotropic activity

R Mechoulam et al. Experientia. .

Abstract

The 1,1-dimethylheptyl homolog of (-)-(3R,4R)-7-hydroxy-delta-6- tetrahydrocannabinol (compound II) is highly psychotropic in mice, rats and pigeons. The (+)-(3S,4S) enantiomer (III) was found to be psychotropically inactive at doses up to several thousand times those of the ED50 of (II).

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