The chicken, the egg, and the elephant: eNOS and NRG1 in fibrosis

Shamama Nishat^{1

2}, Richard J Gumina^{1

2

3}

Affiliations

¹ The Davis Heart and Lung Research Institute, The Ohio State University Wexner Medical Center, Columbus, Ohio.
² Department of Cellular Biology and Physiology, The Ohio State University Wexner Medical Center, Columbus, Ohio.
³ Division of Cardiovascular Medicine, Department of Internal Medicine, The Ohio State University Wexner Medical Center, Columbus, Ohio.

Editorial

Shamama Nishat et al. Am J Physiol Heart Circ Physiol. 2021.

. 2021 Aug 1;321(2):H292-H293.

doi: 10.1152/ajpheart.00308.2021. Epub 2021 Jun 25.

Shamama Nishat^{1

2}, Richard J Gumina^{1

2

3}

¹ The Davis Heart and Lung Research Institute, The Ohio State University Wexner Medical Center, Columbus, Ohio.
² Department of Cellular Biology and Physiology, The Ohio State University Wexner Medical Center, Columbus, Ohio.
³ Division of Cardiovascular Medicine, Department of Internal Medicine, The Ohio State University Wexner Medical Center, Columbus, Ohio.

No abstract available

Keywords: fibrosis; neuregulin; nitric oxide.

Conflict of interest statement

No conflicts of interest, financial or otherwise, are declared by the authors.

Neuregulin-1 compensates for endothelial nitric oxide synthase deficiency.
Shakeri H, Boen JRA, De Moudt S, Hendrickx JO, Leloup AJA, Jacobs G, De Meyer GRY, De Keulenaer GW, Guns PDF, Segers VFM. Shakeri H, et al. Am J Physiol Heart Circ Physiol. 2021 Jun 1;320(6):H2416-H2428. doi: 10.1152/ajpheart.00914.2020. Epub 2021 May 14. Am J Physiol Heart Circ Physiol. 2021. PMID: 33989083

1. Premer C, Kanelidis AJ, Hare JM, Schulman IH. Rethinking endothelial dysfunction as a crucial target in fighting heart failure. Mayo Clin Proc Innov Qual Outcomes 3: 1–13, 2019. doi:10.1016/j.mayocpiqo.2018.12.006. - DOI - PMC - PubMed
1. Geissler A, Ryzhov S, Sawyer DB. Neuregulins: protective and reparative growth factors in multiple forms of cardiovascular disease. Clin Sci (Lond) 134: 2623–2643, 2020. doi:10.1042/CS20200230. - DOI - PMC - PubMed
1. Shakeri H, Boen JRA, De Moudt S, Hendrickx JO, Leloup AJA, Jacobs G, De Meyer GRY, De Keulenaer GW, Guns PDF, Segers VFM. Neuregulin-1 compensates for endothelial nitric oxide synthase deficiency. Am J Physiol Heart Circ Physiol 320: H2416–H2428, 2021. doi:10.1152/ajpheart.00914.2020. - DOI - PubMed
1. Kirabo A, Ryzhov S, Gupte M, Sengsayadeth S, Gumina RJ, Sawyer DB, Galindo CL. Neuregulin-1β induces proliferation, survival and paracrine signaling in normal human cardiac ventricular fibroblasts. J Mol Cell Cardiol 105: 59–69, 2017. doi:10.1016/j.yjmcc.2017.03.001. - DOI - PMC - PubMed
1. Katz SD, Khan T, Zeballos GA, Mathew L, Potharlanka P, Knecht M, Whelan J. Decreased activity of the L-arginine-nitric oxide metabolic pathway in patients with congestive heart failure. Circulation 99: 2113–2117, 1999. doi:10.1161/01.CIR.99.16.2113. - DOI - PubMed