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. 1988;19(3):431-4.
doi: 10.1016/0306-3623(88)90042-0.

Effect of cimetidine on the pharmacokinetics of theophylline

O Shaheen  1 , N A Sliman, W A Al-Turk
Affiliations

Effect of cimetidine on the pharmacokinetics of theophylline

O Shaheen et al. Gen Pharmacol. 1988.

Abstract

1. The effect of the therapeutic doses of cimetidine (400 mg/twice daily) on theophylline metabolism in Jordanian volunteers was studied. 2. The administration of the above therapeutic cimetidine dose did not alter theophylline clearance and elimination half-life. 3. Cimetidine administration also failed to alter the elimination of theophylline metabolites in urine.

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