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Meta-Analysis
. 2022 Jan;132(1):140-154.
doi: 10.1111/jam.15192. Epub 2021 Jul 14.

A meta-analysis of the global prevalence of methicillin-resistant Staphylococcus aureus (MRSA) isolated from clinical and subclinical bovine mastitis

Nawel Zaatout  1 , Djamila Hezil  2
Affiliations
Meta-Analysis

A meta-analysis of the global prevalence of methicillin-resistant Staphylococcus aureus (MRSA) isolated from clinical and subclinical bovine mastitis

Nawel Zaatout et al. J Appl Microbiol. 2022 Jan.

Abstract

Aims: This meta-analysis aims to assess the point prevalence of methicillin-resistant Staphylococcus aureus (MRSA) isolated from bovine mastitis cases at the global level.

Methods and results: Several electronic databases were searched for relevant publications (PubMed, EMBASE, Web of Knowledge and Cochrane Library). Heterogeneity between studies was assessed using the Cochrane Q test and I2 test statistics based on the random-effect model. The potential sources of between-study heterogeneity were evaluated using subgroup analysis and meta-regression. Sensitivity and publication bias analyses were performed. Sixty-six studies with a total of 77,644 mastitis cases were eligible and included in the analysis. The overall pooled prevalence of MRSA was 4·30% (95% CI: 3·24-5·50) with a significant heterogeneity (I2 = 97·48%, p < 0·001). In the subgroup analysis by region, the highest prevalence was found in Asia (6·47%, 95% CI: 4·33-8·97), and the lowest prevalence was reported in Europe (1·18%, 95% CI: 0·18-2·83). The pooled prevalence was significantly higher in clinical mastitis and cases published during 2016-2020.

Conclusions: The results of this study suggest that there is a lower prevalence of MRSA in bovine mastitis. However, its prevalence increased in the past 4 years. Therefore, continuous surveillance is urgently required for monitoring the dissemination of these clinically important bacteria.

Significance of the study: To our knowledge, this is the first meta-analysis to estimate the global prevalence of MRSA isolated from bovine mastitis cases.

Keywords: Staphylococcus aureus; meta-analysis; methicillin-resistant S. aureus; prevalence.

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References

REFERENCES

    1. Abd El-Tawab, A., El Hofy, A., Amaar, A., Sleim, M. & Salem, H. (2016) Molecular characterization for some virulence and antibiotic resistance genes of Staphylococcus aureus isolated from dairy cattle’s subclinical mastitis in EL-Sharkia Governorate. Benha Veterinary Medical Journal, 30, 219-230.
    1. Abed, A.H., Attia, A.S.R. & Atia, A.A. (2018) Genotyping of β-lactams resistant staphylococci isolated from bovine subclinical mastitis. Beni-Suef University Journal of Basic and Applied Sciences, 7, 499-504.
    1. Akkou, M., Bouchiat, C., Antri, K., Bes, M., Tristan, A., Dauwalder, O. et al. (2018) New host shift from human to cows within Staphylococcus aureus involved in bovine mastitis and nasal carriage of animal’s caretakers. Veterinary Microbiology, 223, 173-180.
    1. Al-Azeem, M.W.A., Shaheen, H.M., Abdel, K.G. & Helmy, M.M. (2013) Penicillin resistance against staphylococcal isolates recovered from subclinical mastitis in Sohag City, Egypt. American Journal of Research Communication, 1(15), 115-130.
    1. Algammal, A.M., Enany, M.E., El-Tarabili, R.M., Ghobashy, M.O.I. & Helmy, Y.A. (2020) Prevalence, antimicrobial resistance profiles, virulence and enterotoxins-determinant genes of MRSA isolated from subclinical bovine mastitis in Egypt. Pathogens, 9, 362.

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