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Comment
. 2021 Jun 24;184(13):3356-3357.
doi: 10.1016/j.cell.2021.05.044.

Bacteria make T cell memories in utero

Elaine L Parker  1 , Rachel B Silverstein  1 , Indira U Mysorekar  2
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Comment

Bacteria make T cell memories in utero

Elaine L Parker et al. Cell. .
Free article

Abstract

Education of the human immune system begins in utero via T cell activation and memory development. However, whether part of the education is provided by exposure to microbes in utero remains controversial and unclear. In this issue of Cell, Mishra et al. provide new evidence that the fetal gut may be colonized by bacteria that prime T cell memories.

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Conflict of interest statement

Declaration of interests I.U.M. serves on the Scientific Advisory Board of Luca Biologics. No other conflicts of interest exist.

Comment on

  • Microbial exposure during early human development primes fetal immune cells.
    Mishra A, Lai GC, Yao LJ, Aung TT, Shental N, Rotter-Maskowitz A, Shepherdson E, Singh GSN, Pai R, Shanti A, Wong RMM, Lee A, Khyriem C, Dutertre CA, Chakarov S, Srinivasan KG, Shadan NB, Zhang XM, Khalilnezhad S, Cottier F, Tan ASM, Low G, Chen P, Fan Y, Hor PX, Lee AKM, Choolani M, Vermijlen D, Sharma A, Fuks G, Straussman R, Pavelka N, Malleret B, McGovern N, Albani S, Chan JKY, Ginhoux F. Mishra A, et al. Cell. 2021 Jun 24;184(13):3394-3409.e20. doi: 10.1016/j.cell.2021.04.039. Epub 2021 Jun 1. Cell. 2021. PMID: 34077752 Free PMC article.

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