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Meta-Analysis
. 2021 Sep:150:106694.
doi: 10.1016/j.ypmed.2021.106694. Epub 2021 Jun 22.

Vaccination against COVID-19: A systematic review and meta-analysis of acceptability and its predictors

Qiang Wang  1 , Liuqing Yang  1 , Hui Jin  2 , Leesa Lin  3
Affiliations
Meta-Analysis

Vaccination against COVID-19: A systematic review and meta-analysis of acceptability and its predictors

Qiang Wang et al. Prev Med. 2021 Sep.

Abstract

We aimed to estimate the coronavirus disease 2019 (COVID-19) vaccine acceptance rate and identify predictors associated with acceptance. To this end, we searched PubMed, Web of Science, Cochrane Library, and Embase databases until November 4, 2020. Meta-analyses were performed to estimate the rate with 95% confidence intervals (CI). Predictors were identified to be associated with vaccination intention based on the health belief model framework. Thirty-eight articles, with 81,173 individuals, were included. The pooled COVID-19 vaccine acceptance rate was 73.31% (95%CI: 70.52, 76.01). Studies using representative samples reported a rate of 73.16%. The pooled acceptance rate among the general population (81.65%) was higher than that among healthcare workers (65.65%). Gender, educational level, influenza vaccination history, and trust in the government were strong predictors of COVID-19 vaccination willingness. People who received an influenza vaccination in the last year were more likely to accept COVID-19 vaccination (odds ratio: 3.165; 95%CI: 1.842, 5.464). Protecting oneself or others was the main reason for willingness, and concerns about side effects and safety were the main reasons for unwillingness. National- and individual-level interventions can be implemented to improve COVID-19 vaccine acceptance before large-scale vaccine rollout. Greater efforts could be put into addressing negative predictors associated with willingness.

Keywords: Acceptance; COVID-19; Predictors; Systematic review; Vaccine.

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Conflict of interest statement

The authors declare that they have no known competing financial interests or personal relationships that could have appeared to influence the work reported in this paper.

Figures

Fig. 1
Fig. 1
Flowchart of study selection.
Fig. 2
Fig. 2
COVID-19 vaccination acceptance rate by subgroup†. †HCWs: Healthcare workers, the vertical bar represents the overall pooled rate (0.7331), there were no data in August being reported. *Division came from https://datahelpdesk.worldbank.org/knowledgebase/articles/906519-world-bank-country-and-lending-groups.
Fig. 3
Fig. 3
Estimated COVID-19 vaccination acceptance rate worldwide†. †The vertical bar represents the overall pooled rate (0.7331).
See this image and copyright information in PMC

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