SARS-CoV-2-Related Acute Respiratory Distress Syndrome Uncovers a Patient with Severe Combined Immunodeficiency Disease

Bandar Al-Saud^{1

2}, Khaled M Hazzazi³, Reem Mohammed^{3

4}, Alaa Al Najjar⁵, Tariq Al Hazmi⁶, Dorota Monies⁷, Fowzan S Alkuraya^{4

8}

Affiliations

¹ Department of Pediatrics, Division of Allergy & Immunology, Faisal Specialist Hospital & Research Center, MBC-58, P.O. Box 3354, Riyadh, 11211, King, Saudi Arabia. balsaud@kfshrc.edu.sa.
² College of Medicine, Alfaisal University, Riyadh, Saudi Arabia. balsaud@kfshrc.edu.sa.
³ Department of Pediatrics, Division of Allergy & Immunology, Faisal Specialist Hospital & Research Center, MBC-58, P.O. Box 3354, Riyadh, 11211, King, Saudi Arabia.
⁴ College of Medicine, Alfaisal University, Riyadh, Saudi Arabia.
⁵ Department of Pediatrics, Maternity and Children Hospital, Makkah, Saudi Arabia.
⁶ Department of Pediatrics, Intensive Care Unit, Maternity and Children Hospital, Makkah, Saudi Arabia.
⁷ Department of Clinical Genomics, Center for Genomic Medicine, King Faisal Specialist Hospital and Research Center, Riyadh, Saudi Arabia.
⁸ Department of Translational Genomics, Center for Genomic Medicine, King Faisal Specialist Hospital and Research Center, Riyadh, Saudi Arabia.

Case Reports

Bandar Al-Saud et al. J Clin Immunol. 2021 Oct.

. 2021 Oct;41(7):1507-1510.

doi: 10.1007/s10875-021-01063-x. Epub 2021 Jun 25.

Bandar Al-Saud^{1

2}, Khaled M Hazzazi³, Reem Mohammed^{3

4}, Alaa Al Najjar⁵, Tariq Al Hazmi⁶, Dorota Monies⁷, Fowzan S Alkuraya^{4

8}

¹ Department of Pediatrics, Division of Allergy & Immunology, Faisal Specialist Hospital & Research Center, MBC-58, P.O. Box 3354, Riyadh, 11211, King, Saudi Arabia. balsaud@kfshrc.edu.sa.
² College of Medicine, Alfaisal University, Riyadh, Saudi Arabia. balsaud@kfshrc.edu.sa.
³ Department of Pediatrics, Division of Allergy & Immunology, Faisal Specialist Hospital & Research Center, MBC-58, P.O. Box 3354, Riyadh, 11211, King, Saudi Arabia.
⁴ College of Medicine, Alfaisal University, Riyadh, Saudi Arabia.
⁵ Department of Pediatrics, Maternity and Children Hospital, Makkah, Saudi Arabia.
⁶ Department of Pediatrics, Intensive Care Unit, Maternity and Children Hospital, Makkah, Saudi Arabia.
⁷ Department of Clinical Genomics, Center for Genomic Medicine, King Faisal Specialist Hospital and Research Center, Riyadh, Saudi Arabia.
⁸ Department of Translational Genomics, Center for Genomic Medicine, King Faisal Specialist Hospital and Research Center, Riyadh, Saudi Arabia.

No abstract available

Keywords: Adaptive immunity; COVID-19; Compound heterozygous; JAK3; Lymphopenia; SCID; T cells.

Conflict of interest statement

The authors declare no competing interests.

1. Lu X, Zhang L, Du H, Zhang J, Li YY, Qu J, et al. SARS-CoV-2 infection in children. N Engl J Med. 2020;382(17):1663–1665. doi: 10.1056/NEJMc2005073. - DOI - PMC - PubMed
1. Zhang Q, Bastard P, Liu Z, Le Pen J, Moncada-Velez M, Chen J, et al. Inborn errors of type I IFN immunity in patients with life-threatening COVID-19. Science. 2020;370(6515):eabd4570. doi: 10.1126/science.abd4570. - DOI - PMC - PubMed
1. Meyts I, Bucciol G, Quinti I, Neven B, Fischer A, Seoane E, et al. Coronavirus disease 2019 in patients with inborn errors of immunity: an international study. J Allergy Clin Immunol. 2021;147(2):520–531. doi: 10.1016/j.jaci.2020.09.010. - DOI - PMC - PubMed
1. Delavari S, Abolhassani H, Abolnezhadian F, Babaha F, Iranparast S, Ahanchian H, et al. Impact of SARS-CoV-2 pandemic on patients with primary immunodeficiency. J Clin Immunol. 2021;41(2):345–355. doi: 10.1007/s10875-020-00928-x. - DOI - PMC - PubMed
1. van Oers NSC, Hanners NW, Sue PK, Aquino V, Li QZ, Schoggins JW, et al. SARS-CoV-2 infection associated with hepatitis in an infant with X-linked severe combined immunodeficiency. Clin Immunol. 2021;224:108662. doi: 10.1016/j.clim.2020.108662. - DOI - PMC - PubMed