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Review
. 2021 Sep 5:906:174278.
doi: 10.1016/j.ejphar.2021.174278. Epub 2021 Jun 24.

Ligand modulation of KCNQ-encoded (KV7) potassium channels in the heart and nervous system

Moawiah M Naffaa  1 , Ola A Al-Ewaidat  2
Affiliations
Review

Ligand modulation of KCNQ-encoded (KV7) potassium channels in the heart and nervous system

Moawiah M Naffaa et al. Eur J Pharmacol. .

Abstract

KCNQ-encoded (KV7) potassium channels are diversely distributed in the human tissues, associated with many physiological processes and pathophysiological conditions. These channels are increasingly used as drug targets for treating diseases. More selective and potent molecules on various types of the KV7 channels are desirable for appropriate therapies. The recent knowledge of the structure and function of human KCNQ-encoded channels makes it more feasible to achieve these goals. This review discusses the role and mechanism of action of many molecules in modulating the function of the KCNQ-encoded potassium channels in the heart and nervous system. The effects of these compounds on KV7 channels help to understand their involvement in many diseases, and to search for more selective and potent ligands to be used in the treatment of many disorders such as various types of cardiac arrhythmias, epilepsy, and pain.

Keywords: Channel activator; Channel inhibitor; I(Ks) channels; KCNQ (K(V)7) potassium channels; M-current; PIP(2).

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