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. 2021 Oct;35(10):e14404.
doi: 10.1111/ctr.14404. Epub 2021 Jul 8.

Blood product transfusion and lung transplant outcomes: A systematic review

Jacob A Klapper  1 , Anne C Hicks  2 , Leila Ledbetter  3 , Jessica Poisson  4 , Matthew G Hartwig  1 , Nazish Hashmi  2 , Ian Welsby  2 , Brandi A Bottiger  2
Affiliations

Blood product transfusion and lung transplant outcomes: A systematic review

Jacob A Klapper et al. Clin Transplant. 2021 Oct.

Abstract

The perioperative transfusion of blood products has long been linked to development of acute lung injury and associated with mortality across both medical and surgical patient populations.1,2 The need for blood product transfusion during and after lung transplantation is common and, in many instances, unavoidable. However, this practice may potentially be modifiable.3 In this systematic review, we explore and summarize what is known regarding the impact of blood product transfusion on outcomes following lung transplantation, highlighting the most recent work in this area. Overall, the majority of the literature consists of single center retrospective analyses or the work of multicenter working groups referencing the same database. In the end, there are a number of remaining questions regarding blood product transfusion and their downstream effects on graft function and survival.

Keywords: Blood transfusion; lung transplant; primary graft dysfunction.

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References

REFERENCES

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    1. Ming Y, Liu J, Zhang F, et al. Transfusion of red blood cells, fresh frozen plasma, or platelets is associated with mortality and infection after cardiac surgery in a dose-dependent manner. Anesth Analg. 2020;130:488-497.
    1. Görlinger K, Shore-Lesserson L, Dirkmann D, Hanke AA, Rahe-Meyer N, Tanaka KA. Management of hemorrhage in cardiothoracic surgery. J Cardiothorac Vasc Anesth. 2013;27:S20-34.
    1. Yusen RD, Edwards LB, Dipchand AI, et al. The Registry of the International Society for Heart and Lung Transplantation: thirty-third adult lung and heart-lung transplant report-2016; focus theme: primary diagnostic indications for transplant. J Heart Lung Transplant. 2016;35:1170-1184.
    1. Diamond JM, Lee JC, Kawut SM, et al. Clinical risk factors for primary graft dysfunction after lung transplantation. Heart. 2013;32:S43.

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