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Case Reports
. 2021 Aug;23(4):e13656.
doi: 10.1111/tid.13656. Epub 2021 Jun 27.

Intestinal mucormycosis initially identified by next-generation sequencing of cell-free DNA

Rachel Martin-Blais  1 , Saumya Pathak  2 , Sean Fitzwater  1 , David W Dawson  3 , Anthony E Sisk  3 , Douglas G Farmer  4 , Robert Venick  2 , Nava Yeganeh  1
Affiliations
Case Reports

Intestinal mucormycosis initially identified by next-generation sequencing of cell-free DNA

Rachel Martin-Blais et al. Transpl Infect Dis. 2021 Aug.

Abstract

Mucormycosis is a rare fungal infection that typically affects severely immunocompromised individuals, often resulting in significant morbidity and mortality. Although early and aggressive intervention is necessary to prevent poor outcomes, diagnosis of this infection remains difficult. We report the first case, to our knowledge, of invasive gastrointestinal mucormycosis initially identified by next-generation sequencing of cfDNA from the blood, and discuss the various benefits and challenges which come with new molecular diagnostic techniques.

Keywords: cell-free DNA; invasive fungal infection; mucormycosis; next-generation sequencing; transplant.

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References

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