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Review
. 2022 Jan 1;61(1):103-110.
doi: 10.2169/internalmedicine.7340-21. Epub 2021 Jun 26.

Remission of Angiographically Confirmed Minocycline-induced Renal Polyarteritis Nodosa: A Case Report and Literature Review

Kenichi Yokota  1 , Isao Kurihara  1 , Toshifumi Nakamura  1 , Seishi Nakatsuka  2 , Kazutoshi Miyashita  1 , Sakiko Kobayashi  1 , Ayano Murai-Takeda  1 , Masakatsu Sone  3 , Hiroshi Itoh  1
Affiliations
Review

Remission of Angiographically Confirmed Minocycline-induced Renal Polyarteritis Nodosa: A Case Report and Literature Review

Kenichi Yokota et al. Intern Med. .

Abstract

A 23-year-old man presented with severe hypertension. Based on his history of minocycline treatment for over three years and clinical symptoms, such as myalgias and renovascular hypertension with multiple intrarenal aneurysms, he was diagnosed with minocycline-induced renal polyarteritis nodosa (PAN). After minocycline treatment cessation and management of the hypertension, his blood pressure, renin-aldosterone levels, and urinary protein levels gradually improved. Seven and a half years later, repeated angiography found that the aneurysms had resolved. This is the first report in English describing a case of minocycline-induced renal PAN that was reversed functionally and morphologically without steroids or immunosuppressive drugs.

Keywords: aneurysms; angiography; drug-induced vasculitis; minocycline; polyarteritis nodosa; renovascular hypertension.

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Conflict of interest statement

The authors state that they have no Conflict of Interest (COI).

Figures

Figure 1.
Figure 1.
Contrast-enhanced computed tomography showed multiple wedge-shaped areas of decreased enhancement in both kidneys.
Figure 2.
Figure 2.
Captopril renography showed right-dominant, bilaterally delayed excretion rates. The curve of the right kidney was transiently elevated between 15 and 20 minutes due to measurement of the transient accumulation of RI from the renal pelvis to the proximal tubule. Taking this into account, the T1/2 was estimated to be 16 minutes. L: left, R: right.
Figure 3.
Figure 3.
On initial admission, bilateral renal angiography revealed multiple, intrarenal aneurysms as well as multiple subcapsular areas of decreased enhancements that were suggestive of infarctions (A, B). After seven and a half years, the multiple, intrarenal aneurysms had almost completely resolved (C, D). L: left kidney, R: right kidney. arrow: multiple subcapsular areas of decreased enhancements.
Figure 4.
Figure 4.
Clinical course. ARC: active renin concentration (pg/mL), Cr: creatinine (mg/dL), dBP: diastolic blood pressure, nifedipine CR: nifedipine controlled-release, PAC: plasma aldosterone concentration (pg/mL), sBP: systolic blood pressure, u-pro: urinary protein
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References

    1. Jennette JC, Falk RJ, Bacon PA, et al. . 2012 revised International Chapel Hill Consensus Conference Nomenclature of Vasculitides. Arthritis Rheum 65: 1-11, 2013. - PubMed
    1. Lhote F, Cohen P, Guillevin L. Polyarteritis nodosa, microscopic polyangiitis and Churg-Strauss syndrome. Lupus 7: 238-258, 1998. - PubMed
    1. Pagnoux C, Seror R, Henegar C, et al. . Clinical features and outcomes in 348 patients with polyarteritis nodosa: a systematic retrospective study of patients diagnosed between 1963 and 2005 and entered into the French Vasculitis Study Group Database. Arthritis Rheum 62: 616-626, 2010. - PubMed
    1. Selga D, Mohammad A, Sturfelt G, Segelmark M. Polyarteritis nodosa when applying the Chapel Hill nomenclature--a descriptive study on ten patients. Rheumatology (Oxford) 45: 1276-1281, 2006. - PubMed
    1. Hernández-Rodríguez J, Alba MA, Prieto-González S, Cid MC. Diagnosis and classification of polyarteritis nodosa. J Autoimmun 48-49: 84-89, 2014. - PubMed