Review

. 2021 Jun 11:13:647285.

doi: 10.3389/fnagi.2021.647285. eCollection 2021.

Multidisciplinary Tinnitus Research: Challenges and Future Directions From the Perspective of Early Stage Researchers

Jorge Piano Simoes¹, Elza Daoud², Maryam Shabbir³, Sana Amanat⁴, Kelly Assouly^{5

6

7}, Roshni Biswas^{3

8}, Chiara Casolani^{9

10

11}, Albi Dode¹², Falco Enzler², Laure Jacquemin^{13

14}, Mie Joergensen^{9

15}, Tori Kok¹⁶, Nuwan Liyanage^{17

18}, Matheus Lourenco^{19

20}, Punitkumar Makani^{21

22}, Muntazir Mehdi²³, Anissa L Ramadhani^{24

25}, Constanze Riha²⁶, Jose Lopez Santacruz^{21

22}, Axel Schiller¹, Stefan Schoisswohl¹, Natalia Trpchevska²⁷, Eleni Genitsaridi^{3

28}

Affiliations

¹ Department of Psychiatry and Psychotherapy, University of Regensburg, Regensburg, Germany.
² Centre National de la Recherche Scientifique, Aix-Marseille University, Marseille, France.
³ Hearing Sciences, Mental Health and Clinical Neurosciences, School of Medicine, University of Nottingham, Nottingham, United Kingdom.
⁴ Otology & Neurotology Group CTS 495, Department of Genomic Medicine, GENYO - Centre for Genomics and Oncological Research Pfizer/University of Granada/Junta de Andalucía, PTS, Granada, Spain.
⁵ Department of Otorhinolaryngology and Head & Neck Surgery, University Medical Center Utrecht, Utrecht, Netherlands.
⁶ Department of Clinical and Experimental Neuroscience, University Medical Center Utrecht Brain Center, Utrecht University, Utrecht, Netherlands.
⁷ Cochlear Technology Centre, Mechelen, Belgium.
⁸ Laboratory of Lifestyle Epidemiology, Department of Environmental Health Sciences, Istituto di Ricerche Farmacologiche Mario Negri IRCCS, Milan, Italy.
⁹ Hearing Systems, Department of Health Technology, Technical University of Denmark, Lyngby, Denmark.
¹⁰ Oticon A/S, Smoerum, Denmark.
¹¹ Interacoustics Research Unit, Lyngby, Denmark.
¹² Institute of Databases and Information Systems, Ulm University, Ulm, Germany.
¹³ Department of Otorhinolaryngology Head and Neck Surgery, Antwerp University Hospital, Edegem, Belgium.
¹⁴ Department of Translational Neurosciences, Faculty of Medicine and Health Sciences, Antwerp University, Wilrijk, Belgium.
¹⁵ WS Audiology, Lynge, Denmark.
¹⁶ Ear Institute, University College London, London, United Kingdom.
¹⁷ University of Zurich, Zurich, Switzerland.
¹⁸ Department of Otorhinolaryngology, Head and Neck Surgery, University Hospital Zurich, Zurich, Switzerland.
¹⁹ Experimental Health Psychology, Faculty of Psychology and Neuroscience, Maastricht University, Maastricht, Netherlands.
²⁰ Health Psychology Research Group, Faculty of Psychology and Educational Sciences, University of Leuven, Leuven, Belgium.
²¹ Department of Otorhinolaryngology, Head and Neck Surgery, University of Groningen, University Medical Center Groningen, Groningen, Netherlands.
²² Graduate School of Medical Sciences (Research School of Behavioral and Cognitive Neurosciences), University of Groningen, Groningen, Netherlands.
²³ Institute of Distributed Systems, Ulm University, Ulm, Germany.
²⁴ Radiological Sciences, Mental Health and Clinical Neurosciences, School of Medicine, University of Nottingham, Nottingham, United Kingdom.
²⁵ Sir Peter Mansfield Imaging Centre, School of Medicine, University of Nottingham, Nottingham, United Kingdom.
²⁶ Chair of Neuropsychology, Department of Psychology, University of Zurich, Zurich, Switzerland.
²⁷ Department of Physiology and Pharmacology, Experimental Audiology Laboratory, Karolinska Institutet, Stockholm, Sweden.
²⁸ Nottingham Biomedical Research Centre, National Institute for Health Research, Nottingham, United Kingdom.

PMID: 34177549
PMCID: PMC8225955
DOI: 10.3389/fnagi.2021.647285

Review

Multidisciplinary Tinnitus Research: Challenges and Future Directions From the Perspective of Early Stage Researchers

Jorge Piano Simoes et al. Front Aging Neurosci. 2021.

. 2021 Jun 11:13:647285.

doi: 10.3389/fnagi.2021.647285. eCollection 2021.

Authors

Affiliations

¹ Department of Psychiatry and Psychotherapy, University of Regensburg, Regensburg, Germany.
² Centre National de la Recherche Scientifique, Aix-Marseille University, Marseille, France.
³ Hearing Sciences, Mental Health and Clinical Neurosciences, School of Medicine, University of Nottingham, Nottingham, United Kingdom.
⁴ Otology & Neurotology Group CTS 495, Department of Genomic Medicine, GENYO - Centre for Genomics and Oncological Research Pfizer/University of Granada/Junta de Andalucía, PTS, Granada, Spain.
⁵ Department of Otorhinolaryngology and Head & Neck Surgery, University Medical Center Utrecht, Utrecht, Netherlands.
⁶ Department of Clinical and Experimental Neuroscience, University Medical Center Utrecht Brain Center, Utrecht University, Utrecht, Netherlands.
⁷ Cochlear Technology Centre, Mechelen, Belgium.
⁸ Laboratory of Lifestyle Epidemiology, Department of Environmental Health Sciences, Istituto di Ricerche Farmacologiche Mario Negri IRCCS, Milan, Italy.
⁹ Hearing Systems, Department of Health Technology, Technical University of Denmark, Lyngby, Denmark.
¹⁰ Oticon A/S, Smoerum, Denmark.
¹¹ Interacoustics Research Unit, Lyngby, Denmark.
¹² Institute of Databases and Information Systems, Ulm University, Ulm, Germany.
¹³ Department of Otorhinolaryngology Head and Neck Surgery, Antwerp University Hospital, Edegem, Belgium.
¹⁴ Department of Translational Neurosciences, Faculty of Medicine and Health Sciences, Antwerp University, Wilrijk, Belgium.
¹⁵ WS Audiology, Lynge, Denmark.
¹⁶ Ear Institute, University College London, London, United Kingdom.
¹⁷ University of Zurich, Zurich, Switzerland.
¹⁸ Department of Otorhinolaryngology, Head and Neck Surgery, University Hospital Zurich, Zurich, Switzerland.
¹⁹ Experimental Health Psychology, Faculty of Psychology and Neuroscience, Maastricht University, Maastricht, Netherlands.
²⁰ Health Psychology Research Group, Faculty of Psychology and Educational Sciences, University of Leuven, Leuven, Belgium.
²¹ Department of Otorhinolaryngology, Head and Neck Surgery, University of Groningen, University Medical Center Groningen, Groningen, Netherlands.
²² Graduate School of Medical Sciences (Research School of Behavioral and Cognitive Neurosciences), University of Groningen, Groningen, Netherlands.
²³ Institute of Distributed Systems, Ulm University, Ulm, Germany.
²⁴ Radiological Sciences, Mental Health and Clinical Neurosciences, School of Medicine, University of Nottingham, Nottingham, United Kingdom.
²⁵ Sir Peter Mansfield Imaging Centre, School of Medicine, University of Nottingham, Nottingham, United Kingdom.
²⁶ Chair of Neuropsychology, Department of Psychology, University of Zurich, Zurich, Switzerland.
²⁷ Department of Physiology and Pharmacology, Experimental Audiology Laboratory, Karolinska Institutet, Stockholm, Sweden.
²⁸ Nottingham Biomedical Research Centre, National Institute for Health Research, Nottingham, United Kingdom.

PMID: 34177549
PMCID: PMC8225955
DOI: 10.3389/fnagi.2021.647285

Erratum in

Corrigendum: Multidisciplinary Tinnitus Research: Challenges and Future Directions From the Perspective of Early Stage Researchers.
Simoes JP, Daoud E, Shabbir M, Amanat S, Assouly K, Biswas R, Casolani C, Dode A, Enzler F, Jacquemin L, Joergensen M, Kok T, Liyanage N, Lourenco M, Makani P, Mehdi M, Ramadhani AL, Riha C, Santacruz JL, Schiller A, Schoisswohl S, Trpchevska N, Genitsaridi E. Simoes JP, et al. Front Aging Neurosci. 2021 Aug 9;13:730758. doi: 10.3389/fnagi.2021.730758. eCollection 2021. Front Aging Neurosci. 2021. PMID: 34434102 Free PMC article.

Abstract

Tinnitus can be a burdensome condition on both individual and societal levels. Many aspects of this condition remain elusive, including its underlying mechanisms, ultimately hindering the development of a cure. Interdisciplinary approaches are required to overcome long-established research challenges. This review summarizes current knowledge in various tinnitus-relevant research fields including tinnitus generating mechanisms, heterogeneity, epidemiology, assessment, and treatment development, in an effort to highlight the main challenges and provide suggestions for future research to overcome them. Four common themes across different areas were identified as future research direction: (1) Further establishment of multicenter and multidisciplinary collaborations; (2) Systematic reviews and syntheses of existing knowledge; (3) Standardization of research methods including tinnitus assessment, data acquisition, and data analysis protocols; (4) The design of studies with large sample sizes and the creation of large tinnitus-specific databases that would allow in-depth exploration of tinnitus heterogeneity.

Keywords: big data; heterogeneity; interdisciplinary collaborations; review; standardization; tinnitus; treatment development.

Copyright © 2021 Simoes, Daoud, Shabbir, Amanat, Assouly, Biswas, Casolani, Dode, Enzler, Jacquemin, Joergensen, Kok, Liyanage, Lourenco, Makani, Mehdi, Ramadhani, Riha, Santacruz, Schiller, Schoisswohl, Trpchevska and Genitsaridi.

PubMed Disclaimer

Conflict of interest statement

KA is employed by Cochlear Company. MJ is employed by WS Audiology. CC is employed by Oticon A/S. These relationships have not influenced the work reported in this paper. The remaining authors declare that the research was conducted in the absence of any commercial or financial relationships that could be construed as a potential conflict of interest.

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Biswas R, Schiller A, Casolani C, Daoud E, Dode A, Genitsaridi E, Jacquemin L, Liyanage N, Lourenco M, Makani P, Parameshwarappa V, Riha C, L Santacruz J, Shabbir M, Simoes J, Trpchevska N, Schoisswohl S. Biswas R, et al. Open Res Eur. 2021 Sep 6;1:34. doi: 10.12688/openreseurope.13094.2. eCollection 2021. Open Res Eur. 2021. PMID: 37645158 Free PMC article.

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Multidisciplinary Tinnitus Research: Challenges and Future Directions From the Perspective of Early Stage Researchers

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Multidisciplinary Tinnitus Research: Challenges and Future Directions From the Perspective of Early Stage Researchers

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