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Review
. 2021 Jun 11:12:661173.
doi: 10.3389/fphar.2021.661173. eCollection 2021.

1,2,3-Triazole-Containing Compounds as Anti-Lung Cancer Agents: Current Developments, Mechanisms of Action, and Structure-Activity Relationship

Ting Liang  1 , Xiangyang Sun  2 , Wenhong Li  3 , Guihua Hou  1 , Feng Gao  1
Affiliations
Review

1,2,3-Triazole-Containing Compounds as Anti-Lung Cancer Agents: Current Developments, Mechanisms of Action, and Structure-Activity Relationship

Ting Liang et al. Front Pharmacol. .

Abstract

Lung cancer is the most common malignancy and leads to around one-quarter of all cancer deaths. Great advances have been achieved in the treatment of lung cancer with novel anticancer agents and improved technology. However, morbidity and mortality rates remain extremely high, calling for an urgent need to develop novel anti-lung cancer agents. 1,2,3-Triazole could be readily interact with diverse enzymes and receptors in organisms through weak interaction. 1,2,3-Triazole can not only be acted as a linker to tether different pharmacophores but also serve as a pharmacophore. This review aims to summarize the recent advances in 1,2,3-triazole-containing compounds with anti-lung cancer potential, and their structure-activity relationship (SAR) together with mechanisms of action is also discussed to pave the way for the further rational development of novel anti-lung cancer candidates.

Keywords: anticancer; hybrid molecules; lung cancer; structure–activity relationship; triazole.

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Conflict of interest statement

The authors declare that the research was conducted in the absence of any commercial or financial relationships that could be construed as a potential conflict of interest.

Figures

FIGURE 1
FIGURE 1
Chemical structures of 1,2,3-triazole moiety and carboxyamidotriazole.
FIGURE 2
FIGURE 2
Chemical structures of 1,2,3-triazole–containing chromene/coumarin derivatives one to six.
FIGURE 3
FIGURE 3
Chemical structures of 1,2,3-triazole–containing chalcone derivatives 7–12.
FIGURE 4
FIGURE 4
Chemical structures of 1,2,3-triazole–containing indole derivatives 13–18.
FIGURE 5
FIGURE 5
Chemical structures of 1,2,3-triazole–containing (epi)podophyllotoxin derivatives 19–25.
FIGURE 6
FIGURE 6
Chemical structures of 1,2,3-triazole–containing quinoline/quinolone derivatives 26–34.
FIGURE 7
FIGURE 7
Chemical structures of 1,2,3-triazole–containing pyridine derivatives 35–42.
FIGURE 8
FIGURE 8
Chemical structures of 1,2,3-triazole–containing pyrimidine derivatives 43–53.
FIGURE 9
FIGURE 9
Chemical structures of 1,2,3-triazole–containing quinazoline/nucleoside derivatives 54–57.
FIGURE 10
FIGURE 10
Chemical structures of 1,2,3-triazole–containing steroid derivatives 58–62.
FIGURE 11
FIGURE 11
Chemical structures of 1,2,3-triazole–containing compounds 63–72.
FIGURE 12
FIGURE 12
Chemical structures of 1,2,3-triazole–containing compounds 73–83.
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