Corrigendum: Cinical, Metabolic, and Genetic Analysis and Follow-Up of Eight Patients With HIBCH Mutations Presenting With Leigh/Leigh-Like Syndrome

Abstract

[This corrects the article DOI: 10.3389/fphar.2021.605803.].

Keywords: 2,3-dihydroxy-2-methylbutyrate; C4-OH; HIBCH gene; Leigh/Leigh-like syndrome; children; mitochondrial disorders.

FIGURE 5

NPMDS scores in the peak phase and last assessment. a, All the recruited patients (n = 8); b, Patients who received therapy (Patient 1, 5, 6, 7, 8; n = 5); c, Patients who gave up therapy (Patient 2, 3, 4; n = 3).

FIGURE 6

Patient 1: MRI performance in the peak and recovery phases. (a1, a2): Initial MRI obtained at age 2 years; hyperintensity on T2WI in the globus pallidus (a1), normal cerebral peduncle (a2). (b1, b2): MRI performed at 4 years 5 months during the acute stage; hyperintensity on T2WI in the globus pallidus with swelling on the left side (b1) and in the left cerebral peduncle (b2). (c1, c2): MRI performed at 6 years 1 month during the recovery stage; only slightly hyperintensity on T2WI in globus pallidus (c1), and Abnormal signal disappeared in the cerebral peduncle (c2).