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Review
. 2021 Jun 10:12:562090.
doi: 10.3389/fneur.2021.562090. eCollection 2021.

White Matter Injury After Intracerebral Hemorrhage

Xiongjie Fu  1 , Guoyang Zhou  1 , Jianfeng Zhuang  1 , Chaoran Xu  1 , Hang Zhou  1 , Yucong Peng  1 , Yang Cao  1 , Hanhai Zeng  1 , Jianru Li  1 , Feng Yan  1 , Lin Wang  1 , Gao Chen  1
Affiliations
Review

White Matter Injury After Intracerebral Hemorrhage

Xiongjie Fu et al. Front Neurol. .

Abstract

Spontaneous intracerebral hemorrhage (ICH) accounts for 15% of all stroke cases. ICH is a devastating form of stroke associated with high morbidity, mortality, and disability. Preclinical studies have explored the mechanisms of neuronal death and gray matter damage after ICH. However, few studies have examined the development of white matter injury (WMI) following ICH. Research on WMI indicates that its pathophysiological presentation involves axonal damage, demyelination, and mature oligodendrocyte loss. However, the detailed relationship and mechanism between WMI and ICH remain unclear. Studies of other acute brain insults have indicated that WMI is strongly correlated with cognitive deficits, neurological deficits, and depression. The degree of WMI determines the short- and long-term prognosis of patients with ICH. This review demonstrates the structure and functions of the white matter in the healthy brain and discusses the pathophysiological mechanism of WMI following ICH. Our review reveals that the development of WMI after ICH is complex; therefore, comprehensive treatment is essential. Understanding the relationship between WMI and other brain cells may reveal therapeutic targets for the treatment of ICH.

Keywords: axonal damage; demyelination; spontaneous intracerebral hemorrhage; stroke; white matter injury.

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Conflict of interest statement

The authors declare that the research was conducted in the absence of any commercial or financial relationships that could be construed as a potential conflict of interest.

Figures

Figure 1
Figure 1
The possible pathophysiological factors of white matter injury (WMI) after intracerebral hemorrhage (ICH).
Figure 2
Figure 2
Example of white matter injury (WMI) after intracerebral hemorrhage (ICH). (A) T1-weighted image after ICH. (B,C) Diffusion tensor images of WMI after ICH.
Figure 3
Figure 3
The potential therapeutic strategy of white matter injury (WMI) after intracerebral hemorrhage (ICH).
See this image and copyright information in PMC

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