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. 2021 Jun 10:12:674495.
doi: 10.3389/fneur.2021.674495. eCollection 2021.

Gait Analysis in Progressive Supranuclear Palsy Phenotypes

Marina Picillo  1 , Carlo Ricciardi  2   3 , Maria Francesca Tepedino  1 , Filomena Abate  1 , Sofia Cuoco  1 , Immacolata Carotenuto  1 , Roberto Erro  1 , Gianluca Ricciardelli  4 , Michela Russo  2 , Mario Cesarelli  2   3 , Paolo Barone  1 , Marianna Amboni  1   5
Affiliations

Gait Analysis in Progressive Supranuclear Palsy Phenotypes

Marina Picillo et al. Front Neurol. .

Abstract

The objective of the present study was to describe gait parameters of progressive supranuclear palsy (PSP) phenotypes at early stage verifying the ability of gait analysis in discriminating between disease phenotypes and between the other variant syndromes of PSP (vPSP) and Parkinson's disease (PD). Nineteen PSP (10 PSP-Richardson's syndrome, five PSP-parkinsonism, and four PSP-progressive gait freezing) and nine PD patients performed gait analysis in single and dual tasks. Although phenotypes showed similar demographic and clinical variables, Richardson's syndrome presented worse cognitive functions. Gait analysis demonstrated worse parameters in Richardson's syndrome compared with the vPSP. The overall diagnostic accuracy of the statistical model during dual task was almost 90%. The correlation analysis showed a significant relationship between gait parameters and visuo-spatial, praxic, and attention abilities in PSP-Richardson's syndrome only. vPSP presented worse gait parameters than PD. Richardson's syndrome presents greater gait dynamic instability since the earliest stages than other phenotypes. Computerized gait analysis can differentiate between PSP phenotypes and between vPSP and PD.

Keywords: gait; gait analysis; phenotype; progressive supranuclear palsy; subtype.

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Conflict of interest statement

MP has been supported by the Michael J. Fox Foundation for Parkinson's research. PB received consultancies as a member of the advisory board for Zambon, Lundbeck, UCB, Chiesi, Abbvie, and Acorda. RE received consultancies from Zambon and honoraria from TEVA. The remaining authors declare that the research was conducted in the absence of any commercial or financial relationships that could be construed as a potential conflict of interest.

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