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. 2021 Jun 11:12:601960.
doi: 10.3389/fendo.2021.601960. eCollection 2021.

The Influences of TSH Stimulation Level, Stimulated Tg Level and Tg/TSH Ratio on the Therapeutic Effect of 131I Treatment in DTC Patients

Wei Zheng  1 , Zhongying Rui  1 , Xuan Wang  1 , Ning Li  1 , Jian Tan  1 , Wei Liu  2
Affiliations

The Influences of TSH Stimulation Level, Stimulated Tg Level and Tg/TSH Ratio on the Therapeutic Effect of 131I Treatment in DTC Patients

Wei Zheng et al. Front Endocrinol (Lausanne). .

Abstract

Purpose: To study the influences of pre-ablation TSH stimulation level, sTg and sTg/TSH ratio on the therapeutic effect of the first 131I treatment in DTCs.

Methods: According to the thyroid stimulating hormone (TSH) levels (mU/l), all the 479 differentiated thyroid cancer (DTC) patients were divided into two groups: TSH < 30 and TSH ≥ 30. The TSH ≥ 30 group was divided into three subgroups: 30 ≤ TSH < 60, 60 ≤ TSH < 90 and TSH ≥ 90. The clinical features and the therapeutic effects of the first 131I treatment were analyzed. The cutoffs of stimulated thyroglobulin (sTg) and sTg/TSH ratio were calculated to predict the therapeutic effect of 131I treatment.

Results: Among the three subgroups, the TSH ≥ 90 subgroup was younger and less likely to be associated with cervical lymph node metastasis (LNM). The postoperative levothyroxine (L-T4) dose in the 60 ≤ TSH < 90 subgroup was the lowest. Between the two groups, patients in the TSH < 30 group had higher postoperative L-T4 dose and longer thyroid hormone withdrawal (THW) time. The excellent response rates six months after the first 131I treatment among the three subgroups and between the two groups were not of statistical significance. The distribution of different TSH stimulation levels among each response group was similar. The cutoffs for the better therapeutic effect of the first 131I treatment in sTg and sTg/TSH were < 9.51 ng/ml and < 0.11, respectively. Both univariate and multivariate logistic regressions showed that cervical LNM, distant metastasis, higher sTg and higher sTg/TSH ratio predicted poorer therapeutic effect.

Conclusions: There was no significant influence of TSH stimulation levels before the first 131I treatment on the therapeutic effect of DTC. The sTg/TSH ratio can be considered as another predictor of 131I therapeutic effect.

Keywords: 131I treatment; TSH stimulation level; differentiated thyroid cancer; sTg; sTg/TSH ratio; therapeutic effect.

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Conflict of interest statement

The authors declare that the research was conducted in the absence of any commercial or financial relationships that could be construed as a potential conflict of interest.

Figures

Figure 1
Figure 1
(A) we divided the TSH ≥ 30 patients into three subgroups: 30 ≤ TSH < 60, 60 ≤ TSH < 90 and TSH ≥ 90. The response rate six months after the first 131I treatment among the three subgroups was of no statistical significance (p = 0.657). (B) we merged the three subgroups into the TSH ≥ 30 group. Compared with the TSH < 30 group, the response rate six months after the first 131I treatment was still similar (p = 0.532). (C) the distribution of patients with different TSH stimulation levels in each response group was similar (p = 0.703).
Figure 2
Figure 2
The cutoffs for sTg level and sTg/TSH ratio were 9.51 ng/ml (AUC: 0.790) and 0.11 (AUC: 0.792), respectively. These values had high specificity and moderate sensitivity to predict a better therapeutic effect of the first 131I treatment.
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References

    1. Verburg FA, de Keizer B, Lips CJ, Zelissen PM, de Klerk JM. Prognostic Significance of Successful Ablation With Radioiodine of Differentiated Thyroid Cancer Patients. Eur J Endocrinol (2005) 152(1):33–7. 10.1530/eje.1.01819 - DOI - PubMed
    1. Haugen BR, Alexander EK, Bible KC, Doherty GM, Mandel SJ, Nikiforov YE, et al. . 2015 American Thyroid Association Management Guidelines for Adult Patients With Thyroid Nodules and Differentiated Thyroid Cancer: The American Thyroid Association Guidelines Task Force on Thyroid Nodules and Differentiated Thyroid Cancer. Thyroid (2016) 26(1):1–133. 10.1089/thy.2015.0020 - DOI - PMC - PubMed
    1. Edmonds CJ, Hayes S, Kermode JC, Thompson BD. Measurement of Serum TSH and Thyroid Hormones in the Management of Treatment of Thyroid Carcinoma With Radioiodine. Br J Radiol (1977) 50(599):799–807. 10.1259/0007-1285-50-599-799 - DOI - PubMed
    1. Lawal IO, Nyakale NE, Harry LM, Lengana T, Mokgoro NP, Vorster M, et al. . Higher Preablative Serum Thyroid-Stimulating Hormone Level Predicts Radioiodine Ablation Effectiveness in Patients With Differentiated Thyroid Carcinoma. Nucl Med Commun (2017) 38(3):222–7. 10.1097/MNM.0000000000000640 - DOI - PubMed
    1. Zhao T, Liang J, Guo Z, Li T, Lin Y. In Patients With Low- to Intermediate-Risk Thyroid Cancer, a Preablative Thyrotropin Level of 30 Muiu/Ml Is Not Adequate to Achieve Better Response to 131I Therapy. Clin Nucl Med (2016) 41(6):454–8. 10.1097/RLU.0000000000001167 - DOI - PubMed

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