Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
. 2020 Oct;15(4):165-170.
doi: 10.18502/jthc.v15i4.5942.

Relationship between the Severity of Coronary Artery Disease and Cardiovascular Risk Factors in Acute Coronary Syndrome: Based on Tehran Heart Center's Data Registry

Negar Omidi  1 , Saeed Sadeghian  1 , Mojtaba Salarifar  1 , Arash Jalali  1 , Seyed Hesameddin Abbasi  1 , Negin Yavari  1 , Seyyed Mojtaba Ghorashi  1 , Mohammad Alidoosti  1 , Hamidreza Poorhosseini  1
Affiliations

Relationship between the Severity of Coronary Artery Disease and Cardiovascular Risk Factors in Acute Coronary Syndrome: Based on Tehran Heart Center's Data Registry

Negar Omidi et al. J Tehran Heart Cent. 2020 Oct.

Abstract

Background: Acute coronary syndrome (ACS) is one of the main causes of mortality worldwide. We sought to evaluate the correlation between the severity of coronary artery disease (CAD) and conventional coronary artery risk factors in a large cohort of patients with ACS.

Methods: This study included all patients admitted to the coronary care unit with a diagnosis of ACS between 2003 and 2017. The patients were divided into 2 groups: 1) unstable angina and 2) myocardial infarction. The aims of this study were to evaluate the effects of the risk factors and extension of coronary artery stenosis in patients with ACS according to the Gensini score.

Results: Of a total 40 319 patients who presented with ACS, 18 862 patients (mean age =60.4±11.14 y, male: 67.2%) underwent conventional coronary angiography and met our criteria to enter the final analysis. The median of the Gensini score was 50 (25-88) in the study population. The multivariable analysis showed that age, sex, diabetes mellitus, hypertension, dyslipidemia, family history, cigarette smoking, opium consumption, and myocardial infarction increased the risk of positive Gensini scores. All the aforementioned risk factors, except cigarette smoking and opium consumption, increased the severity of stenosis in those with positive Gensini scores. The strongest relationship was seen vis-à-vis myocardial infarction, sex, and diabetes mellitus.

Conclusion: Our findings suggest that age, sex, diabetes mellitus, dyslipidemia, hypertension, family history, and myocardial infarction have significant effects on the severity of CAD. The obesity paradox in relation to CAD should be taken into consideration and needs further investigation in patients with ACS.

Keywords: Acute coronary syndrome; Coronary artery disease; Myocardial infarction; Risk factors.

PubMed Disclaimer

References

    1. Shyu KG, Wu CJ, Mar GY, Hou CJ, Li AH, Wen MS, Lai WT, Lin SJ, Kuo CT, Hwang JJ, Chiang FT. Clinical characteristics, management and in-hospital outcomes of patients with acute coronary syndrome-observations from the Taiwan ACS full spectrum registry. Acta Cardiol Sin. 2011;27:135–144.
    1. Khaled S, Matahen R. Cardiovascular risk factors profile in patients with acute coronary syndrome with particular reference to left ventricular ejection fraction. Indian Heart J. 2018;70:45–49. - PMC - PubMed
    1. Araújo C, Laszczyńska O, Viana M, Melão F, Henriques A, Borges A, Severo M, Maciel MJ, Moreira I, Azevedo A. Sex differences in presenting symptoms of acute coronary syndrome: the EPIHeart cohort study. BMJ Open. 2018;8:e018798. - PMC - PubMed
    1. World Health Organization. The selection and use of essential medicines: report of the WHO Expert Committee, 2013 (including the 18th WHO model list of essential medicines and the 4th WHO model list of essential medicines for children) World Health Organization. (2014). https://apps.who.int/iris/handle/10665/112729.
    1. Nichols M, Townsend N, Scarborough P, Rayner M. Cardiovascular disease in Europe 2014: epidemiological update. Eur Heart J. 2014;35:2950–2959. - PubMed

LinkOut - more resources