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. 2021 May 23;13(5):e15202.
doi: 10.7759/cureus.15202.

Effect of Buffered Local Anesthesia on Perioperative Pain During Arteriovenous Fistula Surgery: A Randomized Control Trial

Anum Arif  1 , Bismah Riaz  2 , Ahsan Manzoor Bhatti  3 , Nawabzada Zeerak Farhat Sherwani  2 , Raoon Khan  4 , Aima Sohail  5 , Aitizaz Shahid  4 , Syed Hashim Ali Inam  6
Affiliations

Effect of Buffered Local Anesthesia on Perioperative Pain During Arteriovenous Fistula Surgery: A Randomized Control Trial

Anum Arif et al. Cureus. .

Abstract

Objective: This prospective, pilot randomized double-blind study aimed to compare the effects of buffered and non-buffered xylocaine solutions on injection pain and anesthesia effectiveness in patients undergoing arteriovenous fistula surgery.

Material and methods: A total of 100 adult patients meeting inclusion criteria undergoing arteriovenous fistula surgery were included in the study. They were split into two groups at random. The control group received 1% xylocaine dissolved in 5 ml distilled water, while the intervention group received sodium bicarbonate mixed with 1% xylocaine solution as a local anesthetic. The patients were asked to rate the pain of first and subsequent injections on a visual analog scale (VAS). Besides, the need for extra analgesia was investigated. The mean and standard deviation of the data was determined.

Results: During both the first and subsequent injections, the alkalinized local anesthetic group showed substantially lower VAS scores. In the alkalinized local anesthetic group, anesthesia satisfaction was also more than three times higher. Furthermore, the non-alkalinized group's mean analgesic requirement was higher than the intervention group.

Conclusion: Our findings support the effectiveness of the alkalinized local anesthetic solution in minimizing injection pain and increasing anesthesia duration and overall patient's surgical experience in terms of anesthesia satisfaction score.

Keywords: alkalinization; buffered; local anesthetics; pain; sodium bicarbonate.

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Conflict of interest statement

The authors have declared that no competing interests exist.

Figures

Figure 1
Figure 1. CONSORT diagram of the study
Figure 2
Figure 2. Difference in VAS pain score between either group (n= 100)
VAS: visual analog scale.
Figure 3
Figure 3. Satisfaction of patients related to anesthesia in the control group
Figure 4
Figure 4. Satisfaction of patients related to anesthesia in the intervention group
See this image and copyright information in PMC

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