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. 1988 Apr;9(2):147-55.
doi: 10.1007/BF01773736.

Domain structure of the myosin head in correlation-averaged images of shadowed molecules

P J Vibert  1
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Domain structure of the myosin head in correlation-averaged images of shadowed molecules

P J Vibert. J Muscle Res Cell Motil. 1988 Apr.

Abstract

Electron microscope images of rotary shadowed myosin heads and subfragment-1 (S1) have been computationally aligned and averaged using correlation methods. Average images show reproducible detail within the 'pear-shaped' envelope of the head; the major features are invariant in S1 and in intact heads, in two mirror-related views of the head, and in the presence and absence of ATP. The averages support the view that the head contains two main structural domains separated by a cleft, and that the region of the neck close to the head-rod junction is flexible. They also reveal the inadequacy of the conventional method of correcting the measured dimensions of shadowed particles for the supposed thickness of the 'metal coat'.

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References

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    1. J Muscle Res Cell Motil. 1984 Apr;5(2):147-64 - PubMed
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