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. 2021 Apr 26;20(1):697-708.
doi: 10.1007/s40200-021-00801-7. eCollection 2021 Jun.

The association between dietary patterns with severity of coronary artery stenosis, serum leptin-to-adiponectin ratio, and some related risk factors in patients with coronary artery disease

Majid Mohamadshahi  1 , Habib Haybar  2 , Aghdas Mousavi-Borazjani  3 , Mohammadhossein Haghighizadeh  4 , Behnaz Abiri  5
Affiliations

The association between dietary patterns with severity of coronary artery stenosis, serum leptin-to-adiponectin ratio, and some related risk factors in patients with coronary artery disease

Majid Mohamadshahi et al. J Diabetes Metab Disord. .

Abstract

Background: This research aimed to investigate the association between dietary patterns with severity of coronary artery stenosis, serum leptin-to-adiponectin ratio, and some related risk factors in patients with coronary artery disease referred for coronary angiography.

Methods: This cross-sectional study was carried out on 191 men patients with known coronary disease aged 40-70 years whom were admitted to angiography ward of Ahvaz teaching hospital, Ahvaz, Iran. Dietary patterns were investigated using 161-item semi-quantitative food frequency questionnaire. Anthropometric indices; blood pressure; serum levels of adiponectin and leptin, blood levels of glucose, total cholesterol, HDL-C, LDL-C, and triglycerides were measured. Patients were categorized based on the severity of coronary artery disease [number of vessel involved-single (VD1), double (VD2), triple (VD3)].

Results: Three major dietary patterns were recognized using a factor analysis approach: western, healthy, and traditional patterns. Linear regression analysis demonstrated that there was a negative association between healthy dietary pattern with LDL-C, total cholesterol, and triglycerides. This dietary pattern was positively related to HDL-C. Both traditional and western dietary patterns were related to fasting blood glucose level and lipid profile. General obesity was positively associated with traditional and western dietary patterns. There was a positive relationship between central obesity with traditional and western dietary patterns, but a negative association was reported between the healthy dietary pattern and central obesity. Traditional and western dietary patterns demonstrated a significant positive relationship with serum leptin levels and ratio of L/A, and an inverse relationship with adiponectin. Healthy dietary pattern had a significant negative association with serum leptin levels and ratio of L/A. Healthy dietary pattern was negatively related to the severity of vessel stenosis. Patients in the third quartile of healthy dietary pattern were less likely to have vessel stenosis (OR = 43%, 95% CI: 0.07-0.87).

Conclusions: The findings show that adherence to a healthy dietary pattern was negatively associated with coronary artery stenosis and its related risk factors. However, adherence to western and traditional dietary patterns was positively related to coronary artery disease risk factors.

Keywords: Adiponectin; Coronary artery disease; Coronary artery stenosis; Dietary pattern; Leptin; Risk factor.

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Conflict of interest statement

Competing interestsNone.

Figures

Fig. 1
Fig. 1
Study flowchart. FFQ, food frequency questionnaire
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References

    1. Sarutipaiboon I, Settasatian N, Komanasin N, Kukongwiriyapan U, Sawanyawisuth K, Intharaphet P, Senthong V, Settasatian C. Association of Genetic Variations in NRF2, NQO1, HMOX1, and MT with Severity of Coronary Artery Disease and Related Risk Factors. Cardiovasc Toxicol. 2020;20(2):176–189. doi: 10.1007/s12012-019-09544-7. - DOI - PubMed
    1. Gholizadeh E, Ayremlou P, Nouri Saeidlou S. The association between dietary pattern and coronary artery disease: a case-control study. J Cardiovasc Thorac Res. 2020;12(4):294–302. 10.34172/jcvtr.2020.48. Epub 2020 Nov 28. PMID: 33510878; PMCID: PMC7828759. - PMC - PubMed
    1. Oikonomou E, Psaltopoulou T, Georgiopoulos G, Siasos G, Kokkou E, Antonopoulos A, Vogiatzi G, Tsalamandris S, Gennimata V, Papanikolaou A, Tousoulis D. Western Dietary Pattern Is Associated With Severe Coronary Artery Disease. Angiology. 2018;69(4):339–346. doi: 10.1177/0003319717721603. - DOI - PubMed
    1. Iqbal R, Anand S, Ounpuu S, et al. Dietary patterns and the risk of acute myocardial infarction in 52 countries: results of the INTERHEART study. Circulation. 2008;118(19):1929–1937. doi: 10.1161/CIRCULATIONAHA.107.738716. - DOI - PubMed
    1. Panagiotakos DB, Georgousopoulou EN, Pitsavos C, et al. Ten-year (2002–2012) cardiovascular disease incidence and allcause mortality, in urban Greek population: the ATTICA study. Int J Cardiol. 2015;180:178–184. doi: 10.1016/j.ijcard.2014.11.206. - DOI - PubMed

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