Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
Case Reports
. 2021 Sep;68(9):e29196.
doi: 10.1002/pbc.29196. Epub 2021 Jun 27.

Epstein-Barr virus-induced sickle hepatopathy

Alison S Towerman  1   2 , David B Wilson  1   3 , Monica L Hulbert  1
Affiliations
Case Reports

Epstein-Barr virus-induced sickle hepatopathy

Alison S Towerman et al. Pediatr Blood Cancer. 2021 Sep.

Abstract

Sickle hepatopathy comprises a spectrum of disorders that vary in severity. Intravascular sickling and sinusoidal occlusion are the principal drivers of sickle hepatopathy, but infection or autoimmunity can act as triggers. We describe two cases of acute sickle hepatopathy initiated by primary Epstein-Barr virus (EBV) infection, a previously unreported association. The first case entailed a 14-year-old girl with hemoglobin SC (HbSC) disease who developed hepatic sequestration crisis that responded to a simple transfusion of erythrocytes. The second case was that of a 16-year-old boy with HbSC disease who experienced life-threatening intrahepatic cholestasis with multiorgan failure.

Keywords: cholestasis; hemoglobin SC disease; hepatic sequestration; infectious mononucleosis; sickle cell disease.

PubMed Disclaimer

References

REFERENCES

    1. Allali S, Montalembert MD, Brousse V, et al. Hepatobiliary complications in children with sickle cell disease: a retrospective review of medical records from 616 patients. J Clin Med. 2019;8(9):1481.
    1. Shah R, Taborda C, Chawla S. Acute and chronic hepatobiliary manifestations of sickle cell disease: a review. World J Gastrointest Pathophysiol. 2017;8(3):108-116.
    1. Ahn H, Li C, Wang W. Sickle cell hepatopathy: clinical presentation, treatment, and outcome in pediatric and adult patients. Pediatr Blood Cancer. 2005;45(2):184-190.
    1. Pecker LH, Patel N, Creary S, et al. Diverse manifestations of acute sickle cell hepatopathy in pediatric patients with sickle cell disease: a case series. Pediatr Blood Cancer. 2018;65(8):e27060.
    1. Banerjee S, Owen C, Chopra S. Sickle cell hepatopathy. Hepatology. 2001;33(5):1021-1028.

Publication types

LinkOut - more resources